Venco A, Groothold G, Grandi A, Barzizza F, Corradi L, Negri F, Finardi G
Clin Ther. 1985;7(3):347-56.
Indenolol hydrochloride is a recently introduced antihypertensive substance. Although it has beta-adrenoceptor blocking activity, its action is due to total peripheral resistance reduction. We investigated the effects of indenolol therapy on left ventricular performance in 15 patients with essential hypertension. Assessments were made using systolic time intervals and computerized echocardiography. The echocardiographic and mechanocardiographic tracings were recorded three times: at the beginning of the trial, after seven days of placebo, and after three weeks of indenolol treatment. The indenolol therapy significantly decreased (P less than 0.001) systolic and diastolic blood pressures and heart rate in all patients, both in supine and standing positions. After three weeks of treatment, systolic time intervals and echocardiographic determinants of left ventricular function were substantially unchanged in comparison with the basal and placebo evaluations. We conclude that indenolol exerted a marked effect on chronotropism but no demonstrable negative effect on inotropism in patients with essential hypertension. No clinical signs of heart failure were recorded. Side effects were absent, and patient compliance was good in all cases.
盐酸茚萘洛尔是一种最近引入的抗高血压物质。尽管它具有β-肾上腺素能受体阻断活性，但其作用是由于总外周阻力降低。我们研究了茚萘洛尔治疗对15例原发性高血压患者左心室功能的影响。使用收缩期时间间期和计算机化超声心动图进行评估。超声心动图和机械心动图记录三次：试验开始时、安慰剂治疗7天后和茚萘洛尔治疗3周后。茚萘洛尔治疗使所有患者仰卧位和站立位的收缩压、舒张压和心率均显著降低（P<0.001）。治疗3周后，与基础和安慰剂评估相比，收缩期时间间期和左心室功能的超声心动图指标基本未改变。我们得出结论，茚萘洛尔对原发性高血压患者的变时性有显著影响，但对变力性无明显负面影响。未记录到心力衰竭的临床体征。无副作用，所有病例患者依从性良好。
