甲硫氨酸脑啡肽、甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7和甲硫氨酸脑啡肽-精氨酸6-甘氨酸7-亮氨酸8在猪胃窦黏膜胃泌素细胞中的出现情况。
Occurrence of met-enkephalin, met-enkephalin-Arg6-Phe7 and met-enkephalin-Arg6-Gly7-Leu8 in gastrin cells of hog antral mucosa.
作者信息
Jönsson A C
出版信息
Cell Tissue Res. 1985;240(2):361-5. doi: 10.1007/BF00222346.
Region-specific antisera to three enkephalins: met-enkephalin, met-enkephalin-Arg6-Phe7 and met-enkephalin-Arg6-Gly7-Leu8, together with four region specific antisera to progastrin: C-terminal G17 specific, N-terminal G34 specific, cryptic peptides A- and B-specific, were used in immunohistochemical studies of hog antral mucosa. A sub-population (6-10%) of the gastrin-containing endocrine cells (G-cells) was found to react with antisera to met-enkephalin, met-enkephalin-Arg6-Phe7 and met-enkephalin-Arg6-Gly7-Leu8. About 30% of all the enkephalin-containing cells were identified as G-cells. The results indicate that a fraction of G-cells produces both enkephalin-like peptides and gastrin.
针对三种脑啡肽（甲硫脑啡肽、甲硫脑啡肽-精氨酸6-苯丙氨酸7和甲硫脑啡肽-精氨酸6-甘氨酸7-亮氨酸8）的区域特异性抗血清，以及针对胃泌素原的四种区域特异性抗血清（C端G17特异性、N端G34特异性、隐匿肽A和B特异性），被用于猪胃窦黏膜的免疫组织化学研究。发现一部分（6-10%）含胃泌素的内分泌细胞（G细胞）与甲硫脑啡肽、甲硫脑啡肽-精氨酸6-苯丙氨酸7和甲硫脑啡肽-精氨酸6-甘氨酸7-亮氨酸8的抗血清发生反应。所有含脑啡肽的细胞中约30%被鉴定为G细胞。结果表明，一部分G细胞既产生脑啡肽样肽又产生胃泌素。
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