Williams R G, Dockray G J
Brain Res. 1982 May 20;240(1):167-70. doi: 10.1016/0006-8993(82)90657-6.
Antisera to Met-enkephalin and its heptapeptide variant Met-enkephalin Arg6Phe7 were used in immunohistochemistry to study distribution of immunoreactive material in rat basal ganglia. In the pallidum, the Met-enkephalin antiserum, but not the Met-enkephalin Arg6Phe7 antiserum, revealed abundant nerve terminals, whereas in the caudate-putamen the heptapeptide antiserum demonstrated numerous immunoreactive cell bodies that were not shown by the Met-enkephalin antiserum. The differential distribution of immunoreactivity is compatible with distinct physiological roles for the two peptides in basal ganglia.
