Jiang Qingyu, Chen Zhiheng, Jiang Jin, Chen Qianping, Lan Huiyin, Zhu Ji, Mao Wei
Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310000, China; Zhejiang Chinese Medical University, Hangzhou 310053, China; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310000, China; Zhejiang Key Laboratory of Radiation Oncology, Hangzhou 310000, China.
Department of Oncology, Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing, Jiaxing 31400, China.
Crit Rev Oncol Hematol. 2025 May;209:104658. doi: 10.1016/j.critrevonc.2025.104658. Epub 2025 Feb 15.
The activation of the cGAS-STING pathway occurs when tumor cell DNA is damaged by ionizing radiation. Once triggered, this pathway reshapes the tumor immune microenvironment by promoting the maturation, activation, polarization, and immune-killing capacity of immune cells, as well as by inducing the release of interferons and the expression of immune-related genes. In addition, the gut microbiota and various mechanisms of programmed cell death interact with the cGAS-STING pathway, further influencing its function in remodeling the immune microenvironment after radiotherapy. Therefore, investigating the mechanisms of the cGAS-STING pathway in reshaping the tumor immune microenvironment post-radiotherapy can not only optimize the efficacy of combined radiotherapy and immunotherapy but also provide new research directions and potential targets for cancer treatment.
当肿瘤细胞DNA受到电离辐射损伤时，cGAS-STING通路被激活。一旦被触发，该通路通过促进免疫细胞的成熟、激活、极化和免疫杀伤能力，以及诱导干扰素的释放和免疫相关基因的表达，重塑肿瘤免疫微环境。此外，肠道微生物群和多种程序性细胞死亡机制与cGAS-STING通路相互作用，进一步影响其在放疗后重塑免疫微环境中的功能。因此，研究cGAS-STING通路在放疗后重塑肿瘤免疫微环境中的机制，不仅可以优化放疗与免疫治疗联合的疗效，还能为癌症治疗提供新的研究方向和潜在靶点。
