Chen Jinpeng, Wang Sheng, Ding Yue, Xu Duo, Zheng Shiya
Department of General Surgery, Zhongda Hospital Southeast University, Nanjing, Jiangsu, China.
Southeast University Medical School, Nanjing, Jiangsu, China.
Front Cell Dev Biol. 2025 Apr 28;13:1568634. doi: 10.3389/fcell.2025.1568634. eCollection 2025.
Tumor metabolism plays a pivotal role in shaping immune responses within the tumor microenvironment influencing tumor progression, immune evasion, and the efficacy of cancer therapies. Radiotherapy has been shown to impact both tumor metabolism and immune modulation, often inducing immune activation through damage-associated molecular patterns and the STING pathway. In this study, we analyse the particular characteristics of the tumour metabolic microenvironment and its effect on the immune microenvironment. We also review the changes in the metabolic and immune microenvironment that are induced by radiotherapy, with a focus on metabolic sensitisation to the effects of radiotherapy. Our aim is to contribute to the development of research ideas in the field of radiotherapy metabolic-immunological studies.
肿瘤代谢在塑造肿瘤微环境中的免疫反应方面起着关键作用，影响肿瘤进展、免疫逃逸和癌症治疗效果。放疗已被证明会影响肿瘤代谢和免疫调节，通常通过损伤相关分子模式和STING途径诱导免疫激活。在本研究中，我们分析了肿瘤代谢微环境的特殊特征及其对免疫微环境的影响。我们还回顾了放疗诱导的代谢和免疫微环境的变化，重点关注对放疗效果的代谢敏感性。我们的目的是为放疗代谢免疫学研究领域的研究思路发展做出贡献。
