Sachdeva Rishabh, Kumar Priya, Narayan Bhaskar, Augustine Jeyaseelan, Urs Aadithya B
Department of Oral Pathology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
Department of Oral Pathology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
Crit Rev Oncol Hematol. 2025 May;209:104660. doi: 10.1016/j.critrevonc.2025.104660. Epub 2025 Feb 14.
This systematic review aimed to assess the impact of different clinicopathological parameters on the prognosis and survival of mucoepidermoid carcinoma of salivary glands in the pediatric population. It was conducted according to the recommendations of PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis statement). All case reports, case series and observational studies were searched from the following databases: Medline (By PubMed), Web of Science, Scopus and Embase. Cases other than salivary gland mucoepidermoid carcinoma, cases with less than one-year follow-up and articles without any information on recurrence or survival were excluded. Checklist for Analytical Cross-Sectional Studies by The Joanna Briggs Institute was used for risk of bias assessment. Data was extracted and recorded using Excel spreadsheets. Chi-Square test and Kaplan Meier analysis were used. A total of 697 articles were screened, 42 were retrieved for full text screening and 30 articles were selected. Studies with similar methodologies and outcomes were categorized together. The average risk of bias was low. Data was extracted for 143 cases. Prognostic factors that were associated with poor survival outcomes were male gender, TNM staging, tumor grade, margins, lymphovascular and perineural invasion and choice of treatment. Multivariate analysis from all studies were assimilated to calculate an overall predictive strength of each parameter for prognosis and survival. This review concludes that such clinicopathological parameters are valuable prognostic predictors of mucoepidermoid carcinoma of salivary glands in pediatric population and are essential for proper treatment planning and post-treatment quality of life.
本系统评价旨在评估不同临床病理参数对儿童涎腺黏液表皮样癌预后和生存的影响。该评价是根据PRISMA（系统评价与Meta分析优先报告条目声明）的建议进行的。从以下数据库检索了所有病例报告、病例系列和观察性研究：Medline（通过PubMed）、科学网、Scopus和Embase。排除涎腺黏液表皮样癌以外的病例、随访时间少于一年的病例以及未提供任何复发或生存信息的文章。采用乔安娜·布里格斯研究所的分析性横断面研究核对表进行偏倚风险评估。使用Excel电子表格提取和记录数据。采用卡方检验和Kaplan Meier分析。共筛选697篇文章，检索42篇进行全文筛选，最终选择30篇文章。将方法和结果相似的研究归为一类。平均偏倚风险较低。提取了143例病例的数据。与不良生存结局相关的预后因素包括男性、TNM分期、肿瘤分级、切缘、淋巴管和神经周围侵犯以及治疗选择。汇总所有研究的多变量分析，以计算每个参数对预后和生存的总体预测强度。本评价得出结论，这些临床病理参数是儿童涎腺黏液表皮样癌有价值的预后预测指标，对于合理的治疗规划和治疗后生活质量至关重要。
