Ho Fai Fai, Gao Yin-Yan, Chen Yuting, Wang Betty Huan, Wu Justin Che Yuen, Zheng Hong, Cheung Yin Ting, Lam Chun Sing, Wang Maggie Haitian, Wu Irene Xin-Yin, Mao Chen, Chung Vincent Chi Ho
School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong.
Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Aliment Pharmacol Ther. 2025 May;61(9):1519-1531. doi: 10.1111/apt.70031. Epub 2025 Feb 17.
The combined effects of some modifiable lifestyle factors on incident inflammatory bowel disease (IBD) are uncertain.
To evaluate the combined association between healthy lifestyle behaviours and IBD incidence.
This population-based prospective cohort study used data from the UK Biobank. We included 105,715 participants aged 40-70 who had no IBD diagnosis at baseline in the analyses. The five healthy lifestyle behaviours that we studied were never smoking, optimal sleep, high level of vigorous physical activity, high dietary quality, and moderate alcohol intake. The outcome was the overall incidence of IBD and individual incidences of Crohn's disease (CD) and ulcerative colitis (UC). We derived hazard ratios (HR) and 95% confidence intervals (CI) for associations.
The multivariable adjusted HRs (95% CI) associated with having 1, 2 and 3-5 healthy lifestyle behaviours for IBD incidence compared with those with none of these behaviours were 0.75 (0.59-0.97), 0.72 (0.56-0.92), and 0.50 (0.37-0.68), respectively (p for trend < 0.001). We observed similar findings for CD and UC. Only never smoking exhibited significant independent inverse associations with the overall incidence of IBD (HR 0.70, 95% CI 0.58-0.83, p < 0.001) and the incidence of UC (HR 0.58, 95% CI 0.48-0.72, p < 0.001).
Healthy lifestyle behaviours are significantly associated with lower IBD incidence in middle-aged and elderly individuals, suggesting the potential of lifestyle modifications as a primary prevention strategy for IBD.
一些可改变的生活方式因素对炎症性肠病（IBD）发病的综合影响尚不确定。
评估健康生活方式行为与IBD发病率之间的综合关联。
这项基于人群的前瞻性队列研究使用了英国生物银行的数据。我们纳入了105715名年龄在40至70岁之间、基线时未被诊断为IBD的参与者进行分析。我们研究的五种健康生活方式行为分别是从不吸烟、最佳睡眠、高水平的剧烈体育活动、高饮食质量和适度饮酒。结局指标是IBD的总体发病率以及克罗恩病（CD）和溃疡性结肠炎（UC）的个体发病率。我们得出了关联的风险比（HR）和95%置信区间（CI）。
与没有这些健康生活方式行为的人相比，具有1种、2种和3至5种健康生活方式行为与IBD发病率相关的多变量调整后HR（95%CI）分别为0.75（0.59 - 0.97）、0.72（0.56 - 0.92）和0.50（0.37 - 0.68）（趋势p < 0.001）。我们在CD和UC中观察到了类似的结果。只有从不吸烟与IBD的总体发病率（HR 0.70，95%CI 0.58 - 0.83，p < 0.001）和UC的发病率（HR 0.58，95%CI 0.48 - 0.72，p < 0.001）呈现出显著的独立负相关。
健康的生活方式行为与中老年个体较低的IBD发病率显著相关，这表明生活方式的改变作为IBD的一级预防策略具有潜力。
