Sun Sishen, Wang Danshu, Dan Lintao, Fu Tian, Chen Jie, Zhang Yao, Sun Jing, Zou Duowu
Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Centre for Global Health, Zhejiang University School of Medicine, Hangzhou, China.
Phytother Res. 2024 Dec;38(12):5782-5792. doi: 10.1002/ptr.8341. Epub 2024 Sep 30.
evidence from animal experiments indicates that anthocyanin supplements can contribute to intestinal health. Nevertheless, no evidence has linked dietary anthocyanins to the prevention potential against inflammatory bowel disease (IBD) in humans. We leveraged data from 188,044 IBD-free individuals (mean age 59 years; 55.2% females) from the prospective cohort UK Biobank. The anthocyanin intake was estimated using dietary information from validated 24 h dietary recalls. Incident IBD was ascertained via national health-related records. Genetic susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) was estimated by polygenic risk scores and further categorized into low- and high-risk groups by median value. The Cox proportional regression model was applied to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). During the mean follow-up of 9.7 years, we documented 255 CD and 606 UC. We found that compared with participants with the lowest quartiles of anthocyanin intake, those in the highest quartiles were associated with 24% (95% CI 6%-38%, p = 0.012; p-trend = 0.003) and 35% (95% CI 16%-49%, p = 0.001; p-trend < 0.001) reduced risk of IBD and UC, respectively. The inverse associations were stronger (p-interaction = 0.022) among individuals with a high genetic risk of UC. We did not observe a significant association between anthocyanin intake and CD (p-trend = 0.536). Higher dietary anthocyanin intake was associated with reduced risk of IBD and UC, but not CD. Genetic factors may modify the influence of dietary anthocyanin on UC susceptibility, and possible mechanisms need to be further elucidated in the future.
动物实验证据表明，补充花青素有助于肠道健康。然而，尚无证据表明膳食中的花青素对人类预防炎症性肠病（IBD）具有潜在作用。我们利用了来自前瞻性队列英国生物银行的188,044名无IBD个体（平均年龄59岁；55.2%为女性）的数据。花青素摄入量通过经过验证的24小时饮食回忆中的饮食信息进行估算。通过国家健康相关记录确定新发IBD。通过多基因风险评分估计克罗恩病（CD）和溃疡性结肠炎（UC）的遗传易感性，并通过中位数进一步分为低风险和高风险组。应用Cox比例回归模型估计风险比（HR）和95%置信区间（CI）。在平均9.7年的随访期间，我们记录了255例CD和606例UC。我们发现，与花青素摄入量处于最低四分位数的参与者相比，处于最高四分位数的参与者患IBD和UC的风险分别降低了24%（95%CI 6%-38%，p = 0.012；p趋势 = 0.003）和35%（95%CI 16%-49%，p = 0.001；p趋势 < 0.001）。在UC遗传风险高的个体中，这种负相关更强（p交互作用 = 0.022）。我们未观察到花青素摄入量与CD之间存在显著关联（p趋势 = 0.536）。较高的膳食花青素摄入量与IBD和UC风险降低相关，但与CD无关。遗传因素可能会改变膳食花青素对UC易感性的影响，未来需要进一步阐明其可能机制。
