Shuai Rong, He Yuxing, Yang Dongqian, Zhang Yingying, Zhang Li
Department of Laboratory Medicine, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, China.
Department of Laboratory Medicine, Affiliated Wuxi Fifth Hospital of Jiangnan University, Wuxi, China.
Front Nutr. 2025 Jan 31;12:1511952. doi: 10.3389/fnut.2025.1511952. eCollection 2025.
Recent studies have shown an association between atherogenic index of plasma (AIP) and nonalcoholic fatty liver disease (NAFLD), but the association in a population of pregnant women remains unclear.
Our study aimed to examine the association between AIP and NAFLD in pregnant Korean women.
Our study used publicly available data from Korea, which recruited singleton pregnant women between November 2014 and September 2016 who were at 10-14 weeks of gestation. The presence of NAFLD was diagnosed by liver ultrasound. AIP was calculated as log10 (TG/HDL). Participants were grouped according to AIP tertile: T1 (< 0.16, = 195), T2 (0.16-0.32, = 195), and T3 (>0.32, = 196). Logistic regression models were used to estimate the relationship between AIP and NAFLD. Subgroup and sensitivity analyses were conducted to explore the stability of this relationship. Restricted cubic spline (RCS) curve fitting was employed to investigate potential non-linear associations.
After excluding data on missing variables, 586 singleton pregnant women were finally included. The subjects included in the study had an average AIP of 0.22 (0.11, 0.37), and NAFLD occurred in 110 (18.8%) pregnant women. We observed a positive linear association between AIP and NAFLD (OR = 1.33, 95% CI: 1.19-1.48), which persisted after adjusting for potential confounders (OR = 1.2, 95% CI: 1.06-1.37). When AIP was used as a categorical variable, after adjusting for covariates, the NAFLD risk was significantly higher in the highest tertile of AIP than in the lowest group (OR = 2.02, 95% CI: 1.11-3.68). Their correlations were stable across subgroups and sensitivity analyses.
In this secondary analysis of a prospective cohort study of pregnant Korean women, AIP was found to be positively associated with NAFLD. These outcomes might be used to screen for NAFLD in pregnant women.
最近的研究表明血浆致动脉粥样硬化指数（AIP）与非酒精性脂肪性肝病（NAFLD）之间存在关联，但在孕妇群体中的关联尚不清楚。
我们的研究旨在探讨韩国孕妇中AIP与NAFLD之间的关联。
我们的研究使用了来自韩国的公开数据，该研究招募了2014年11月至2016年9月期间妊娠10 - 14周的单胎孕妇。通过肝脏超声诊断NAFLD的存在。AIP计算为log10（甘油三酯/高密度脂蛋白）。参与者根据AIP三分位数分组：T1（<0.16，n = 195），T2（0.16 - 0.32，n = 195）和T3（>0.32，n = 196）。使用逻辑回归模型估计AIP与NAFLD之间的关系。进行亚组分析和敏感性分析以探讨这种关系的稳定性。采用受限立方样条（RCS）曲线拟合来研究潜在的非线性关联。
在排除缺失变量的数据后，最终纳入了586名单胎孕妇。研究中的受试者平均AIP为0.22（0.11，0.37），110名（18.8%）孕妇发生了NAFLD。我们观察到AIP与NAFLD之间存在正线性关联（OR = 1.33，95% CI：1.19 - 1.48），在调整潜在混杂因素后该关联仍然存在（OR = 1.2，95% CI：1.06 - 1.37）。当将AIP用作分类变量时，在调整协变量后，AIP最高三分位数组的NAFLD风险显著高于最低组（OR = 2.02，95% CI：1.11 - 3.68）。它们的相关性在亚组分析和敏感性分析中是稳定的。
在这项对韩国孕妇进行的前瞻性队列研究的二次分析中，发现AIP与NAFLD呈正相关。这些结果可能用于筛查孕妇中的NAFLD。
