Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330006, Jiangxi, China.
Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center, Nanchang, Jiangxi, China.
Cardiovasc Diabetol. 2023 Jan 30;22(1):19. doi: 10.1186/s12933-023-01740-8.
Although a great deal of scientific evidence on the epidemiological risk factors for diabetes and prediabetes has been accumulated, there is still insufficient evidence to explore sex-related differences. The aim of this study was to examine sex-specific differences in the effect of the atherogenic index of plasma (AIP) on prediabetes and diabetes.
This cross-sectional study included data from 10099 American adults. The exposure variable was the AIP, which was defined as log10 (triglycerides/high-density lipoprotein cholesterol). The outcome variables included prediabetes and diabetes defined by the 2013 American Diabetes Association guidelines.
The median age (mean ± SD) was 48.51 ± 18.42 years, and the average value (SD) of the AIP was - 0.09 (0.34). The prevalence of prediabetes was 40.24%, and that of diabetes was 21.32%. Overall, there was a significant positive association between the AIP and prediabetes and diabetes (per 1-unit increment in the AIP: OR, 2.49; 95% CI 1.75, 3.54). The multivariate logistic regression model demonstrated that for each unit increment in the AIP, the prediabetes and diabetes prevalence increased 4.96-fold among female participants (OR 4.96, 95% CI 2.68, 9.18) but not among male participants. We found that the AIP was not related to the prevalence of prediabetes or diabetes (OR 1.41; 95% CI 0.87, 2.29) among males. There was an interaction between sex and the AIP (P for interaction < 0.0001).
This study showed that a higher AIP was significantly associated with an increased prevalence of prediabetes and diabetes, and the above relationships occurred only among women and not men.
尽管已经积累了大量关于糖尿病和糖尿病前期的流行病学风险因素的科学证据，但仍缺乏探索性别差异的证据。本研究旨在探讨血浆致动脉粥样硬化指数（AIP）对糖尿病前期和糖尿病的影响是否存在性别差异。
本横断面研究纳入了 10099 名美国成年人的数据。暴露变量为 AIP，定义为 log10（甘油三酯/高密度脂蛋白胆固醇）。结局变量包括根据 2013 年美国糖尿病协会指南定义的糖尿病前期和糖尿病。
中位年龄（均数±标准差）为 48.51±18.42 岁，AIP 的平均值（标准差）为-0.09（0.34）。糖尿病前期的患病率为 40.24%，糖尿病的患病率为 21.32%。总体而言，AIP 与糖尿病前期和糖尿病呈显著正相关（AIP 每增加 1 单位：比值比，2.49；95%置信区间，1.753.54）。多变量 logistic 回归模型显示，对于 AIP 的每个单位增加，女性参与者中糖尿病前期和糖尿病的患病率增加 4.96 倍（比值比 4.96，95%置信区间 2.689.18），而男性参与者中则没有增加。我们发现，AIP 与男性中糖尿病前期或糖尿病的患病率无关（比值比 1.41；95%置信区间 0.87~2.29）。性别与 AIP 之间存在交互作用（P 交互<0.0001）。
本研究表明，较高的 AIP 与糖尿病前期和糖尿病的患病率增加显著相关，而且这种关系仅发生在女性中，而不是男性中。
