食品防腐剂乙酸钠（E262）和亚硫酸钠（E221）对人淋巴细胞的遗传毒性作用分析。
Analysis of genotoxic effects of food preservatives sodium acetate (E262) and sodium sulfite (E221) in human lymphocytes.
作者信息
Altunkaynak Pinar, Avuloglu-Yilmaz Ece
机构信息
Department of Molecular Medicine, Institute of Health Sciences, Amasya University, 05100 Amasya, Turkey.
Department of Health Information Systems, School of Technical Sciences, Amasya University, 05100 Amasya, Turkey.
出版信息
Food Sci Biotechnol. 2024 Oct 30;34(3):699-708. doi: 10.1007/s10068-024-01731-9. eCollection 2025 Feb.
Food preservatives are a large class of food additives that generally prevent microbiological spoilage. Sodium acetate (SA) and sodium sulfite (SS) are food preservatives, and the aim of this study was to investigate their genotoxic and cytotoxic effects. The genotoxic effects of SA and SS were examined by chromosomal aberrations (CA) and micronucleus (MN) assays in human lymphocytes in vitro. In addition, the effects of these two preservative additives on mitotic index (MI) and nuclear division index (NDI) were also investigated. SA and SS significantly induced CAs and MN frequencies and caused a decrease in MI especially at higher concentrations. Neither food preservative caused any change in the NDI. In the light of the data obtained, it was concluded that SA and SS may have cytotoxic and genotoxic effects on human lymphocytes, especially at high concentrations. Therefore, their use at lower concentrations, which may be safer, should be encouraged.
食品防腐剂是一大类食品添加剂，通常可防止微生物腐败。乙酸钠（SA）和亚硫酸钠（SS）是食品防腐剂，本研究的目的是调查它们的遗传毒性和细胞毒性作用。通过体外人淋巴细胞的染色体畸变（CA）和微核（MN）试验检测SA和SS的遗传毒性作用。此外，还研究了这两种防腐剂添加剂对有丝分裂指数（MI）和核分裂指数（NDI）的影响。SA和SS显著诱导CA和MN频率，并导致MI降低，尤其是在较高浓度时。两种食品防腐剂均未引起NDI的任何变化。根据获得的数据得出结论，SA和SS可能对人淋巴细胞具有细胞毒性和遗传毒性作用，尤其是在高浓度时。因此，应鼓励使用浓度较低、可能更安全的它们。
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