Wang Ying, Li Zhibang, Ji Lingli, Sun Jiao, Gao Fei, Yu Ruiqing, Li Kai, Wang Wenjun, Zhao Weiwei, Zhong Qi-Zhi, Ge Shaohua, Li Jianhua
Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore.
Mater Today Bio. 2025 Jan 27;31:101525. doi: 10.1016/j.mtbio.2025.101525. eCollection 2025 Apr.
Bacteria are common infectious pathogens that can cause invasive and potentially life-threatening infections. Ionic liquids have emerged as a novel class of alternatives to antibiotics, however their inherent hydrophobicity and immiscible in water exhibits poor adhesion to bacteria and diminishes its utilization and bioavailability for infection control. Herein, an adhesive metal phenolic encapsulated ionic liquid choline and geranate (CAGE@MPN) microcapsules is designed to address the aforementioned challenges and remove bacterial biofilm infections. The CAGE@MPN microcapsules are prepared through self-assembly of quercetin and ferrous ions on the interface of CAGE and water metal-phenolic coordination. The MPN interface can stabilize the micro liquid and effectively adhere to bacterial surfaces. The microcapsules can disrupt bacterial cell walls to facilitate the release of cellular contents and destruct the biofilm, thereby exerting a pronounced bactericidal effect. The bactericidal effect of CAGE@MPN microcapsules is demonstrated in a murine model of () skin infection. The proposed adhesive micro-liquid system offers a promising strategy for noninvasive and efficient removal of bacterial biofilm infection.
细菌是常见的传染性病原体，可引起侵袭性且可能危及生命的感染。离子液体已成为一类新型抗生素替代品，然而其固有的疏水性以及在水中不混溶的特性使其对细菌的粘附性较差，从而降低了其在感染控制中的利用率和生物利用度。在此，设计了一种粘附性金属酚类包裹离子液体胆碱和香叶酸盐（CAGE@MPN）微胶囊，以应对上述挑战并消除细菌生物膜感染。CAGE@MPN微胶囊是通过槲皮素和亚铁离子在CAGE与水的界面上进行自组装以及金属-酚类配位制备而成。MPN界面可稳定微液并有效粘附于细菌表面。微胶囊可破坏细菌细胞壁，促进细胞内容物释放并破坏生物膜，从而发挥显著的杀菌作用。CAGE@MPN微胶囊在（）皮肤感染的小鼠模型中证实了其杀菌效果。所提出的粘附性微液系统为无创且高效地消除细菌生物膜感染提供了一种有前景的策略。
