Wells I C, Durr M P, Grabner B J, Holladay F P, Campbell A S, Zielinski C M, Hammeke M D, Egan J D
Clin Physiol Biochem. 1985;3(1):8-15.
A successful dog model of the continuous ambulatory peritoneal dialysis patient was developed. These preparations were employed in initial studies of the effects of single amino acid-containing dialysis solutions on the losses of protein and amino acids into the dialysate. A decrease of about 40% in the loss of total amino acids into the dialysate was observed when DL-serine-containing dialysis solutions were employed. The addition of DL-serine, L-lysine, or DL-alanine to the dialysis solutions diminished protein loss into the dialysate by 27-55%. DL-Glutamic acid and DL-aspartic acid were ineffective in this regard.
建立了一个成功的持续性非卧床腹膜透析患者的犬模型。这些制剂被用于初步研究含单一氨基酸的透析液对蛋白质和氨基酸向透析液中丢失的影响。当使用含DL-丝氨酸的透析液时，观察到透析液中总氨基酸的丢失减少了约40%。向透析液中添加DL-丝氨酸、L-赖氨酸或DL-丙氨酸可使蛋白质向透析液中的丢失减少27%-55%。在这方面，DL-谷氨酸和DL-天冬氨酸无效。
