Deeb Maya, Tandon Parul, Huang Vivian, Gallinger Zane R
Department of Medicine, University of Toronto, Toronto, ON, Canada.
Division of Gastroenterology, Mount Sinai Hospital, Toronto, ON, Canada.
Obstet Med. 2025 Mar;18(1):46-49. doi: 10.1177/1753495X231173061. Epub 2023 May 8.
Pregnancy-onset inflammatory bowel disease (POIBD) is a rare diagnosis that has been associated with diagnostic delay and increased risk of hospitalization compared with inflammatory bowel disease diagnosed outside of pregnancy. There is a paucity of data on the clinical presentation and risk factors associated with maternal and fetal outcomes of POIBD. We present a 29-year-old patient who presented with acute severe ulcerative colitis at 24 weeks gestational age whose course was complicated by delayed diagnosis and therapy, colonic perforation, colectomy, prolonged hospitalization, and neonatal prematurity. The case illustrates the high index for suspicion required for making this diagnosis and the prevention of maternal and neonatal morbidity, together with a growing need to advocate for timely investigations and in-patient management in unwell pregnant patients.
妊娠起病的炎症性肠病（POIBD）是一种罕见的诊断，与非妊娠时诊断的炎症性肠病相比，其诊断延迟且住院风险增加。关于POIBD的临床表现以及与母婴结局相关的危险因素的数据很少。我们报告一名29岁患者，其在妊娠24周时出现急性重症溃疡性结肠炎，病程因诊断和治疗延迟、结肠穿孔、结肠切除术、长期住院以及新生儿早产而复杂化。该病例说明了做出此诊断所需的高度怀疑指数以及预防母婴发病，同时也凸显了越来越需要倡导对不适的孕妇进行及时检查和住院治疗。
