Grgić Nino, Tarle Marko, Perić Ante, Potočki Slavica, Pašalić Daria, Perić Berislav
Department of Oral and Maxillofacial Surgery, School of Dental Medicine, University of Zagreb, Dubrava University Hospital, Zagreb, Croatia.
School of Dental Medicine, University of Zagreb, Zagreb, Croatia.
Acta Clin Croat. 2024 Apr;63(1):134-141. doi: 10.20471/acc.2024.63.01.16.
The most frequent surgical procedure in oral surgery is extraction of mandibular third molars, which could be associated with postoperative complications such as pain, swelling, and trismus. We aimed to investigate the association of salivary urea and antioxidative enzyme activities with the intensity of postoperative pain after wisdom tooth extraction. This cross-sectional prospective study included 66 subjects (median age 25, range 17-47 years). Salivary urea and superoxide dismutase (SOD) were determined by enzymatic colorimetric tests. The questionnaire for study participants included demographic and history data, as well as data on personal experience of pain in grade 0-10 according to the visual analog scale (VAS). Grading 1-3 was considered as low (VAS-1), 4-6 mild (VAS-2) and 7-10 as severe pain (VAS-3). Moderate positive correlation was recorded between urea concentration and SOD activity in saliva (r=0.46). Moderate negative correlations were found between urea salivary concentration and VAS grading value reported after 12 hours (r=0.51). The concentrations of urea significantly differed among the three VAS categories (p<0.001), whereas salivary SOD activities did not differ among the categories. Preoperative salivary urea concentration and SOD activity might be associated with postsurgical pain after surgical removal of mandibular third molars.
口腔外科最常见的手术是下颌第三磨牙拔除术，该手术可能会引发术后并发症，如疼痛、肿胀和牙关紧闭。我们旨在研究唾液尿素和抗氧化酶活性与智齿拔除术后疼痛强度之间的关联。这项横断面前瞻性研究纳入了66名受试者（年龄中位数为25岁，范围为17 - 47岁）。通过酶比色法测定唾液尿素和超氧化物歧化酶（SOD）。研究参与者的问卷包括人口统计学和病史数据，以及根据视觉模拟量表（VAS）对0 - 10级疼痛个人体验的数据。1 - 3级被视为轻度疼痛（VAS - 1），4 - 6级为中度疼痛（VAS - 2），7 - 10级为重度疼痛（VAS - 3）。唾液中尿素浓度与SOD活性之间存在中度正相关（r = 0.46）。唾液尿素浓度与12小时后报告的VAS分级值之间存在中度负相关（r = 0.51）。三种VAS类别之间尿素浓度存在显著差异（p < 0.001），而唾液SOD活性在各类别之间无差异。下颌第三磨牙拔除术后，术前唾液尿素浓度和SOD活性可能与术后疼痛有关。
