Wu Yuankai, Tan Hayden Weng Siong, Lin Jin-Yi, Shen Han-Ming, Wang Haihe, Lu Guang
Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Liver Res. 2023 Feb 19;7(1):56-70. doi: 10.1016/j.livres.2023.02.002. eCollection 2023 Mar.
Autophagy is a highly conserved process in which cytosolic contents are degraded by the lysosome, which plays an important role in energy and nutrient balance, and protein or organelle quality control. The liver is the most important organ for metabolism. Studies to date have revealed a significant role of autophagy in the maintenance of liver homeostasis under basal and stressed conditions, and the impairment of autophagy has been closely linked to various liver diseases. Therefore, a comprehensive understanding of the roles of autophagy in liver diseases may help in the development of therapeutic strategies via targeting autophagy. In this review, we will summarize the latest understanding of the molecular mechanisms of autophagy and systematically discuss its implications in various liver diseases, including alcohol-related liver disease, non-alcoholic fatty liver disease, viral hepatitis, hepatocellular carcinoma, and acetaminophen-induced liver injury.
自噬是一种高度保守的过程，在该过程中，胞质内容物被溶酶体降解，溶酶体在能量和营养平衡以及蛋白质或细胞器质量控制中发挥重要作用。肝脏是新陈代谢最重要的器官。迄今为止的研究表明，自噬在基础和应激条件下维持肝脏内环境稳定方面发挥着重要作用，自噬功能受损与多种肝脏疾病密切相关。因此，全面了解自噬在肝脏疾病中的作用可能有助于通过靶向自噬来制定治疗策略。在这篇综述中，我们将总结对自噬分子机制的最新认识，并系统地讨论其在各种肝脏疾病中的意义，包括酒精性肝病、非酒精性脂肪性肝病、病毒性肝炎、肝细胞癌和对乙酰氨基酚诱导的肝损伤。
