Kuyucu Melda, Erdogan Kadri Murat, Adiyaman Duygu, Konuralp Atakul Bahar, Golbasi Hakan, Kutbay Yasar Bekir, Gokmen Karasu Ayse Filiz, Ozeren Mehmet
Department of Obstetrics and Gynecology, Bezmialem Vakif University Medical Faculty, Istanbul, Turkey.
Department of Obstetrics and Gynecology, Division of Perinatology, Tepecik Training and Research Hospital, Izmir, Turkey.
Medicine (Baltimore). 2025 Feb 14;104(7):e41582. doi: 10.1097/MD.0000000000041582.
This study shares our 5-year experience with chorionic villus sampling (CVS) and analyzes the indications, results, and complications of this procedure. We conducted a retrospective analysis of data from singleton pregnancies that underwent CVS between 2015 and 2020 at the Maternal-Fetal Medicine Unit of Health Science University, Izmir Tepecik Research, and Training Hospital. Maternal demographics, indications, karyotype results, and pregnancy outcomes were recorded. We retrospectively analyzed data from 468 CVS procedures, conducted between 2015 and 2020. The most common indications for CVS were positive screening test results in the first trimester, fetal structural abnormalities, and increased nuchal translucency (NT) observed during ultrasound. Fetal structural abnormalities had the highest detection rate, at 34.5% for chromosomal abnormalities, followed by increased NT and first-trimester screen-positive test results (26.9% and 11.3%), respectively. The culture success rate was 96.3% (451 out of 468). The most prevalent chromosomal abnormalities were numerical, including Trisomy 21 (10.9%), Trisomy 18 (4.2%), and Trisomy 13 (1.9%). Results could not be obtained in 17 patients (3.6%); 12 (2.5%) were due to insufficient samples and culture failure, while 5 (1.06%) were due to maternal contamination. Amniocentesis was required as a secondary sampling in 24 cases (5.1%) and performed in 17 cases (3.6%). This study emphasizes the significance of CVS in prenatal diagnosis and the management of high-risk pregnancies. However, we must be aware of the associated risks and limitations, which include culture success rates, inconclusive results, and the occasional need for secondary sampling.
本研究分享了我们在绒毛取样（CVS）方面的5年经验，并分析了该操作的适应症、结果及并发症。我们对2015年至2020年在伊兹密尔特佩奇克研究与培训医院健康科学大学母胎医学科接受CVS的单胎妊娠数据进行了回顾性分析。记录了产妇人口统计学资料、适应症、核型结果及妊娠结局。我们回顾性分析了2015年至2020年间进行的468例CVS操作的数据。CVS最常见的适应症是孕早期筛查试验结果阳性、胎儿结构异常以及超声检查时观察到的颈项透明层（NT）增厚。胎儿结构异常的检出率最高，染色体异常为34.5%，其次是NT增厚和孕早期筛查阳性试验结果（分别为26.9%和11.3%）。培养成功率为96.3%（468例中的451例）。最常见的染色体异常是数目异常，包括21三体（10.9%）、18三体（4.2%）和13三体（1.9%）。17例患者（3.6%）未能获得结果；12例（2.5%）是由于样本不足和培养失败，5例（1.06%）是由于母体污染。24例（5.1%）需要进行二次取样羊水穿刺，其中17例（3.6%）进行了操作。本研究强调了CVS在产前诊断和高危妊娠管理中的重要性。然而，我们必须意识到其相关风险和局限性，包括培养成功率、结果不明确以及偶尔需要二次取样。
