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经典半弓置换术与半弓置换术及杂交非覆膜开放式支架置入术治疗急性DeBakey I型主动脉夹层的倾向评分匹配分析

Classic hemiarch versus hemiarch and hybrid noncovered open stenting for acute DeBakey type I dissection-a propensity score-matched analysis.

作者信息

Pitts Leonard, Montagner Matteo, Kofler Markus, Seeber Fabian, Heck Roland, Sündermann Simon, Buz Semih, Starck Christoph, Falk Volkmar, Kempfert Jörg

机构信息

Deutsches Herzzentrum der Charité (DHZC), Department of Cardiothoracic and Vascular Surgery, Augustenburger Platz 1, 13353 Berlin, Germany.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.

出版信息

Eur J Cardiothorac Surg. 2025 Feb 4;67(2). doi: 10.1093/ejcts/ezaf055.

Abstract

OBJECTIVES

This study investigates early and midterm outcomes after surgery for acute DeBakey type I dissection between classic hemiarch replacement and additional open noncovered stenting of the aortic arch.

METHODS

Patients who underwent surgery for acute DeBakey type I dissection receiving solely hemiarch replacement (2015-2022) or additional open noncovered stenting of the aortic arch (2018-2022) using the 'Ascyrus Medical Dissection Stent' (AMDS) were included. After propensity score matching, the groups were compared in terms of clinical and radiological outcomes.

RESULTS

A total of 261 patients (155 hemiarch, 106 AMDS) were included. After matching, the cohort comprised 2 balanced groups with 108 patients (54 each group): 30-day mortality was 19% in the hemiarch group versus 15% in the AMDS group [P = 0.61, odds ratio (OR) = 0.77 (confidence interval (CI) 0.27-2.12)]. New postoperative stroke [P = 0.99, OR = 0.98 (CI 0.11-8.43)] and revision for malperfusion did not differ [P = 0.38, OR = 1.70 (CI 0.53-5.99)]. The incidence of new distal anastomotic entries was significantly lower in the AMDS group with 17% vs 45% in the hemiarch group [P = 0.028, OR = 0.35 (CI 0.13-0.87)]. True lumen expansion was significantly improved in the aortic arch [P = 0.006, OR = 3.15 (CI 1.41-7.34)] and stented portion of the descending aorta [P < 0.001, OR = 8.51 (CI 3.65-21.24)] as well as false lumen thrombosis in the aortic arch [P = 0.048, OR = 2.24 (CI 1.02-5.07)]. Two-year survival did not differ (P = 0.170).

CONCLUSIONS

Additional AMDS implantation shows similar clinical outcomes, reduces the risk for new distal anastomotic entries and may be associated with superior positive aortic remodelling in the aortic arch and stented portion of the descending aorta. Long-term results regarding aortic remodelling and reintervention rate are highly needed.

摘要

目的

本研究调查了经典半弓置换术与主动脉弓附加开放无覆膜支架置入术治疗急性德巴基I型夹层手术后的早期和中期结果。

方法

纳入2015年至2022年仅接受半弓置换术或2018年至2022年使用“Ascyrus Medical Dissection Stent”(AMDS)进行主动脉弓附加开放无覆膜支架置入术治疗急性德巴基I型夹层的患者。经过倾向评分匹配后,比较两组的临床和影像学结果。

结果

共纳入261例患者(155例半弓置换术,106例AMDS)。匹配后,队列包括两个平衡组,每组108例患者(每组54例):半弓置换术组30天死亡率为19%,AMDS组为15%[P = 0.61,优势比(OR)= 0.77(置信区间(CI)0.27 - 2.12)]。术后新发卒中[P = 0.99,OR = 0.98(CI 0.11 - 8.43)]和因灌注不良进行的翻修手术无差异[P = 0.38,OR = 1.70(CI 0.53 - 5.99)]。AMDS组新的远端吻合口入口发生率显著低于半弓置换术组,分别为17%和45%[P = 0.028,OR = 0.35(CI 0.13 - 0.87)]。主动脉弓[P = 0.006,OR = 3.15(CI 1.41 - 7.34)]和降主动脉支架置入部分[P < 0.001,OR = 8.51(CI 3.65 - 21.24)]的真腔扩张以及主动脉弓假腔血栓形成[P = 0.048,OR = 2.24(CI 1.02 - 5.07)]均有显著改善。两年生存率无差异(P = 0.170)。

结论

附加AMDS植入显示出相似的临床结果,降低了新的远端吻合口入口风险,并且可能与主动脉弓和降主动脉支架置入部分更好的主动脉正向重塑相关。非常需要关于主动脉重塑和再次干预率的长期结果。

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