University of Alberta, Edmonton, Alberta, Canada.
University of Toronto, Toronto, Ontario, Canada.
Can J Cardiol. 2024 Mar;40(3):470-475. doi: 10.1016/j.cjca.2023.09.034. Epub 2023 Oct 13.
A distal anastomotic new entry tear (DANE) can occur at the time of surgical repair for acute type A aortic dissection (ATAAD). This study aimed to compare the occurrence of DANE following a standard hemiarch repair with that following a hemiarch repair with an uncovered arch dissection stent.
All patients who received a hemiarch repair or a hemiarch repair with an Ascyrus Medical Dissection Stent (AMDS) for ATAAD from 2017 to 2021 were included. Baseline and intra- and postoperative characteristics were collected. All available pre- and postoperative computed tomographic scans were analysed. The primary outcome measures were the incidence of DANE, positive aortic remodelling, mortality, and aortic reintervention rates at last follow-up.
A total of 114 patients underwent repair of Debakey I ATAAD during the study period with either an isolated hemiarch (n = 77) or a hemiarch with AMDS (n = 37). There was no significant difference in mortality (P = 0.768) or other in-hospital adverse events. During the follow-up period, DANE occurred in 43.3% (n = 26) of the isolated hemiarch group and in 11.8% (n = 4) of the hemiarch with AMDS group (P = 0.002). The incidence of false lumen thrombosis and obliteration favoured the AMDS group in the aortic arch (P = 0.029), the proximal descending thoracic aorta (P = 0.031), and level of pulmonary artery bifurcation (P = 0.044).
The incidence of DANE is significantly reduced with the addition of an AMDS at the time of hemiarch repair for ATAAD repair. Further follow-up is necessary to identify late aortic complications that may have been prevented by reducing the incidence of postoperative DANE.
在急性 A 型主动脉夹层(ATAAD)的手术修复过程中,可能会出现远端吻合口新入口撕裂(DANE)。本研究旨在比较标准半弓修复与半弓修复加 Ascyrus 医疗解剖支架(AMDS)治疗 ATAAD 后 DANE 的发生情况。
纳入 2017 年至 2021 年期间接受半弓修复或半弓修复加 Ascyrus 医疗解剖支架(AMDS)治疗 ATAAD 的所有患者。收集基线和围手术期特征。分析所有可获得的术前和术后 CT 扫描。主要观察指标为 DANE、主动脉正性重塑、死亡率和最后一次随访时的主动脉再介入率。
研究期间共有 114 例患者接受 Debakey I ATAAD 修复,其中 77 例行单纯半弓修复,37 例行半弓加 AMDS 修复。两组死亡率(P=0.768)或其他院内不良事件无显著差异。在随访期间,单纯半弓修复组 DANE 发生率为 43.3%(n=26),半弓加 AMDS 修复组为 11.8%(n=4)(P=0.002)。AMDS 组在主动脉弓(P=0.029)、降胸主动脉近端(P=0.031)和肺动脉分叉水平(P=0.044)的假腔血栓形成和闭塞发生率更高。
在 ATAAD 半弓修复时附加 AMDS 可显著降低 DANE 的发生率。需要进一步随访以确定可能因减少术后 DANE 发生率而预防的晚期主动脉并发症。