Hadi Tri Hastono Setyo, Santoso Budi, Hardianto Gatut, Kurniawati Eighty Mardiyan
Doctoral Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Department of Obstetrics and Gynecology, Dr. Soetomo General Academic Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Obstet Gynecol Sci. 2025 Mar;68(2):131-138. doi: 10.5468/ogs.24282. Epub 2025 Feb 18.
Vaginal dryness and dyspareunia are frequent complaints among postmenopausal women. Studies have shown that isoflavones reduce the severity of menopausal symptoms. This study aimed to evaluate the effects of isoflavones on vaginal dryness and dyspareunia in postmenopausal women. PubMed, ScienceDirect, and Cochrane Library electronic databases were searched until June 15, 2024. Revman 5.4 software (The Nordic Cochrane Centre, Copenhagen, Denmark) was used to analyze the data. Ten randomized controlled trials (RCTs), totaling 675 participants, were included in the isoflavone treatment, and the duration was between 4 and 48 weeks. For the meta-analysis, four and two RCTs were conducted to analyze vaginal dryness and dyspareunia in postmenopausal women before and after isoflavone treatment, respectively. The analysis results for vaginal dryness showed a significant change after isoflavone therapy, whereas those for dyspareunia did not show a significant change. The random-effects estimation of the mean difference was -1.29, and 95% confidence interval (CI) was -2.53 to -0.04 (p=0.04) for vaginal dryness, and -0.82, with a 95% CI of -3.51 to 1.87 (p=0.55) for dyspareunia. This meta-analysis concluded that isoflavones have a significant effect on relieving vaginal dryness but have no impact on dyspareunia in postmenopausal women. Numerous larger, long-term trials are needed to fully assess their effects and efficacy.
阴道干燥和性交困难是绝经后女性常见的主诉。研究表明，异黄酮可减轻更年期症状的严重程度。本研究旨在评估异黄酮对绝经后女性阴道干燥和性交困难的影响。检索了PubMed、ScienceDirect和Cochrane图书馆电子数据库，检索截止至2024年6月15日。使用Revman 5.4软件（丹麦哥本哈根北欧Cochrane中心）进行数据分析。异黄酮治疗纳入了10项随机对照试验（RCT），共675名参与者，持续时间为4至48周。在荟萃分析中，分别进行了4项和2项RCT，以分析绝经后女性在异黄酮治疗前后的阴道干燥和性交困难情况。阴道干燥的分析结果显示，异黄酮治疗后有显著变化，而性交困难的分析结果未显示出显著变化。阴道干燥的平均差异随机效应估计值为-1.29，95%置信区间（CI）为-2.53至-0.04（p=0.04），性交困难的平均差异随机效应估计值为-0.82，95%CI为-3.51至1.87（p=0.55）。该荟萃分析得出结论，异黄酮对缓解绝经后女性的阴道干燥有显著作用，但对性交困难没有影响。需要进行大量规模更大、时间更长的试验来全面评估其效果和疗效。
