Sarebani Zinat, Chegini Venus, Chen Hui, Aali Ehsan, Mirzadeh Monirsadat, Abbaspour Mohammadreza, Griffiths Mark D, Alimoradi Zainab
Students research committee, School of Nursing & Midwifery, University of Technology Sydney, Vltimo, Australia.
Department Obstetrics and Gynecology School of Medicine, University of Technology Sydney, Vltimo, Australia.
Obstet Gynecol Sci. 2023 May;66(3):208-220. doi: 10.5468/ogs.22038. Epub 2023 Feb 24.
Vaginal atrophy, the second most common complication of menopause, can lead to sexual dysfunction. This study evaluated the effect of a vitamin D vaginal suppository on sexual functioning in postmenopausal women.
This three-arm randomized controlled trial was conducted between August 2019 and August 2020. The sample comprised 105 postmenopausal women who were referred to comprehensive health service centers to receive postmenopausal care. The inclusion criteria were as follows: (i) being menopausal for at least 1 year, (ii) being married, (iii) being sexually active, and (iv) having sexual desire. Participants were randomly assigned to three groups for 8 weeks of treatment: intervention (vaginal suppository containing 1,000 units of vitamin D3), placebo (vaginal suppository placebo), or control (no treatment). The main outcome measure was sexual functioning, which was assessed using the Female Sexual Function Scale (FSFI) 4 times during the study (i.e., 1 month before the intervention, immediately after the intervention, 1 month after the intervention, and 2 months after the intervention).
Immediately and 1 month after the trial, the intervention group had the highest FSFI score, followed by the placebo group, both of which were significantly higher than those of the control group (P<0.05). At the 2-month follow-up, the intervention and placebo groups had similar FSFI scores (P=0.08), both of which were significantly higher than those in the control group (P=0.001 and P=0.03, respectively).
Vitamin D vaginal suppositories were more effective at improving sexual functioning among postmenopausal women in the short-term and appeared to prevent aging-related sexual functioning decline in the long term.
阴道萎缩是绝经后第二常见的并发症，可导致性功能障碍。本研究评估了维生素D阴道栓剂对绝经后女性性功能的影响。
本三臂随机对照试验于2019年8月至2020年8月进行。样本包括105名绝经后女性，她们被转介到综合健康服务中心接受绝经后护理。纳入标准如下：（i）绝经至少1年；（ii）已婚；（iii）有性生活；（iv）有性欲。参与者被随机分为三组，进行为期8周的治疗：干预组（含1000单位维生素D3的阴道栓剂）、安慰剂组（阴道栓剂安慰剂）或对照组（不治疗）。主要结局指标是性功能，在研究期间使用女性性功能量表（FSFI）进行4次评估（即干预前1个月、干预后立即、干预后1个月和干预后2个月）。
在试验后立即和1个月时，干预组的FSFI评分最高，其次是安慰剂组，两者均显著高于对照组（P<0.05）。在2个月的随访中，干预组和安慰剂组的FSFI评分相似（P=0.08），两者均显著高于对照组（分别为P=0.001和P=0.03）。
维生素D阴道栓剂在短期内更有效地改善绝经后女性的性功能，并且从长期来看似乎可以预防与衰老相关的性功能下降。
