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广泛心房纤维化与顽固性心房颤动:一例报告及文献简要综述

Extensive Atrial Fibrosis and Recalcitrant Atrial Fibrillation: A Case Report and Brief Literature Review.

作者信息

Asuka Edinen, Arole Olugbenga, Ndakotsu Andrew

机构信息

Internal Medicine and Preventive Medicine, Griffin Hospital, Derby, USA.

Internal Medicine, Griffin Hospital, Derby, USA.

出版信息

Cureus. 2025 Feb 17;17(2):e79169. doi: 10.7759/cureus.79169. eCollection 2025 Feb.

DOI:10.7759/cureus.79169
PMID:39963291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11832057/
Abstract

Atrial fibrillation is one of the most common supraventricular arrhythmias. It has multiple etiologies, some of which include advanced age, hypertension, valvular heart disease, hyperthyroidism, sleep apnea, ischemic heart disease, cardiomyopathy, and certain medications. Herein, we will discuss a case of extensive atrial fibrosis in a 57-year-old male with recalcitrant atrial fibrillation, the significant role extensive atrial fibrosis plays in the recurrence of atrial fibrillation, a brief pathophysiologic interplay between both pathologies based on current literature and research, and various imaging modalities and treatment options utilized in these cases. Likewise, we will also outline some challenges faced or worth keeping in mind when using the various imaging modalities pertaining to the above subject matter.

摘要

心房颤动是最常见的室上性心律失常之一。它有多种病因,其中一些包括高龄、高血压、瓣膜性心脏病、甲状腺功能亢进、睡眠呼吸暂停、缺血性心脏病、心肌病以及某些药物。在此,我们将讨论一例57岁男性顽固性心房颤动伴广泛心房纤维化的病例,广泛心房纤维化在心房颤动复发中所起的重要作用,基于当前文献和研究二者之间简短的病理生理相互作用,以及这些病例中使用的各种成像方式和治疗选择。同样,我们还将概述在使用与上述主题相关的各种成像方式时所面临的一些挑战或值得牢记的要点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efeb/11832057/135530698ddd/cureus-0017-00000079169-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efeb/11832057/10886f75ac40/cureus-0017-00000079169-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efeb/11832057/135530698ddd/cureus-0017-00000079169-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efeb/11832057/10886f75ac40/cureus-0017-00000079169-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efeb/11832057/135530698ddd/cureus-0017-00000079169-i02.jpg

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本文引用的文献

1
Atrial Fibrosis in Atrial Fibrillation: Mechanistic Insights, Diagnostic Challenges, and Emerging Therapeutic Targets.心房颤动中的心房纤维化:机制洞察、诊断挑战及新兴治疗靶点
Int J Mol Sci. 2024 Dec 30;26(1):209. doi: 10.3390/ijms26010209.
2
Translation of pathophysiological mechanisms of atrial fibrosis into new diagnostic and therapeutic approaches.心房纤维化病理生理机制向新诊断和治疗方法的转化。
Nat Rev Cardiol. 2025 Apr;22(4):225-240. doi: 10.1038/s41569-024-01088-w. Epub 2024 Oct 23.
3
2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
2023 ACC/AHA/ACCP/HRS 指南:心房颤动的诊断与管理——美国心脏病学会/美国心脏协会联合临床实践指南委员会的报告。
Circulation. 2024 Jan 2;149(1):e1-e156. doi: 10.1161/CIR.0000000000001193. Epub 2023 Nov 30.
4
Atrial fibrosis and substrate based characterization in atrial fibrillation: Time to move forwards.心房纤维化和房颤的基质特征:向前迈进的时候到了。
J Cardiovasc Electrophysiol. 2021 Apr;32(4):1147-1160. doi: 10.1111/jce.14987. Epub 2021 Mar 17.
5
Atrial fibrosis underlying atrial fibrillation (Review).心房纤维化在心房颤动中的作用(综述)。
Int J Mol Med. 2021 Mar;47(3). doi: 10.3892/ijmm.2020.4842. Epub 2021 Jan 15.