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巴西慢性肾脏病合并重症新型冠状病毒肺炎患者的姑息治疗:一项在四级医院开展的回顾性研究

Palliative care for patients with chronic kidney disease and severe COVID-19 in Brazil: a retrospective study in a quaternary hospital.

作者信息

Correa Tulio L, Guelli Mariana Sandoval Terra Campos, Carvalho Ricardo Tavares de

机构信息

Palliative Care Team, Clinics Hospital, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Palliative Care Team, Clinics Hospital, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.

出版信息

Ann Palliat Med. 2025 Jan;14(1):4-12. doi: 10.21037/apm-24-99.

Abstract

BACKGROUND

Patients with chronic kidney disease (CKD) have many special needs in the areas of symptom management, advanced care planning, and end-of-life care. We aimed to evaluate the palliative care (PC) provided to patients with CKD admitted with severe coronavirus disease 2019 (COVID-19) at the Clinics Hospital of the University of Sao Paulo Faculty of Medicine during the first wave of the pandemic.

METHODS

A retrospective observational study was conducted in a quaternary hospital. Patients assisted by the PC team with CKD in 2020 were selected according to a protocol for identifying patient at an elevated risk of death who require PC support. The clinical and demographic characteristics, as well as the outcomes, were assessed using electronic records.

RESULTS

A total of 217 patients with CKD were included in the study, of whom 44.2% were admitted to the intensive care unit (ICU). Patients with CKD had an increased relative risk (RR) of death [1.31, 95% confidence interval (CI): 1.12-1.53] but were not assisted by the PC team to a higher degree. Eighty patients with CKD (83.3%) died without being assisted by the PC team. Dialysis treatment and CKD grades were not significantly associated with PC assistance.

CONCLUSIONS

Although patients with CKD experienced higher mortality rates, they did not receive PC at a significantly greater frequency and many died without receiving adequate end-of-life care during the COVID-19 pandemic in Brazil.

摘要

背景

慢性肾脏病(CKD)患者在症状管理、晚期护理规划和临终关怀等方面有许多特殊需求。我们旨在评估在疫情第一波期间,圣保罗大学医学院临床医院为因严重2019冠状病毒病(COVID-19)入院的CKD患者提供的姑息治疗(PC)。

方法

在一家四级医院进行了一项回顾性观察研究。根据一项识别需要PC支持的高死亡风险患者的方案,选择了2020年由PC团队护理的CKD患者。使用电子记录评估临床和人口统计学特征以及结局。

结果

共有217例CKD患者纳入研究,其中44.2%入住重症监护病房(ICU)。CKD患者的死亡相对风险(RR)增加[1.31,95%置信区间(CI):1.12 - 1.53],但未得到PC团队更高程度的护理。80例CKD患者(83.3%)在未得到PC团队护理的情况下死亡。透析治疗和CKD分级与PC护理无显著关联。

结论

在巴西的COVID-19大流行期间,尽管CKD患者死亡率较高,但他们接受PC的频率并未显著更高,许多患者在未接受充分临终关怀的情况下死亡。

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