Zhang Tao, Wang Shuai, Li Dongming, Wang Yifei, Cao Xueyuan
Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Eur J Cancer Prev. 2025 Feb 18. doi: 10.1097/CEJ.0000000000000963.
Colorectal cancer (CRC) poses a significant health burden in Europe, but comprehensive studies on this region are limited.
Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2021, we analyzed the regional distribution and temporal trends of the CRC and early-onset CRC burden in Europe from 1990 to 2021. Decomposition analysis was applied to quantify the contributions of population growth, aging, and epidemiological changes. The research also evaluated major risk factors associated with CRC and early-onset CRC.
The burden of CRC in Europe was found to be higher than the global average. While the age-standardized incidence rate (ASIR) increased, both the age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life years rate (ASDR) decreased. Early-onset CRC exhibits similar distribution characteristics and patterns of change. Males had a significantly higher CRC burden than females. Population aging was the primary driver of increased burden in Europe. Risk factor analysis revealed that low whole grain intake and high red meat consumption were the primary contributors to the elevated ASMR and ASDR of CRC and early-onset CRC. Additionally, the CRC and early-onset CRC burden associated with high BMI and high fasting plasma glucose showed an increasing trend.
The overall burden of CRC and early-onset CRC in Europe remains higher than the global level, with increasing ASIR and decreasing ASMR and ASDR. Targeted prevention and control strategies should be developed based on the major risk factors for CRC. Older adults and men should be prioritized for interventions.
结直肠癌（CRC）在欧洲造成了重大的健康负担，但针对该地区的全面研究有限。
利用《2021年全球疾病、伤害及风险因素负担研究》的数据，我们分析了1990年至2021年欧洲结直肠癌和早发性结直肠癌负担的区域分布及时间趋势。采用分解分析来量化人口增长、老龄化和流行病学变化的贡献。该研究还评估了与结直肠癌和早发性结直肠癌相关的主要风险因素。
发现欧洲的结直肠癌负担高于全球平均水平。虽然年龄标准化发病率（ASIR）有所上升，但年龄标准化死亡率（ASMR）和年龄标准化伤残调整生命年率（ASDR）均有所下降。早发性结直肠癌呈现出相似的分布特征和变化模式。男性的结直肠癌负担显著高于女性。人口老龄化是欧洲负担增加的主要驱动因素。风险因素分析显示，全谷物摄入量低和红肉消费量高是结直肠癌和早发性结直肠癌ASMR和ASDR升高的主要原因。此外，与高体重指数和高空腹血糖相关的结直肠癌和早发性结直肠癌负担呈上升趋势。
欧洲结直肠癌和早发性结直肠癌的总体负担仍高于全球水平，ASIR上升，ASMR和ASDR下降。应根据结直肠癌的主要风险因素制定有针对性的预防和控制策略。老年人和男性应优先接受干预。
