Cho Eun Hye, Kim Jee Ah, Park Min-Seung, Kwon Min-Jung, Park Hyosoon, Woo Hee-Yeon
Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
PLoS One. 2025 Feb 18;20(2):e0318847. doi: 10.1371/journal.pone.0318847. eCollection 2025.
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease worldwide. Accurate assessment of liver fibrosis is essential for the prognosis and management of NAFLD. Mean platelet volume (MPV), an index of platelet activation, has been associated with liver fibrosis in various chronic liver diseases; however, its role in NAFLD remains uncertain.
This study analyzed data from 70,830 patients with NAFLD who underwent a comprehensive health examination between 2015 and 2019. Patients were stratified into three groups based on the fibrosis-4 (FIB-4) index: low (<1.30), indeterminate (1.30-2.67), and high (>2.67). We evaluated the differences in MPV among these groups and analyzed the association between MPV and the FIB-4 index.
MPV varied significantly across the three groups categorized by the FIB-4 index (p < 0.001). Additionally, a weak but statistically significant positive correlation was observed between MPV and the FIB-4 index (rho = 0.170, p < 0.001). Multivariable linear regression adjusted for multiple covariates showed that MPV remained significantly associated with the FIB-4 index (β = 0.01, p < 0.001).
MPV may serve as a supplementary non-invasive marker for assessing liver fibrosis in patients with NAFLD. Further studies are required to validate these findings and explore the utility of MPV in conjunction with other non-invasive markers.
非酒精性脂肪性肝病（NAFLD）是全球慢性肝病最常见的病因。准确评估肝纤维化对于NAFLD的预后和管理至关重要。平均血小板体积（MPV）是血小板活化的一个指标，在各种慢性肝病中已被证明与肝纤维化有关；然而，其在NAFLD中的作用仍不明确。
本研究分析了2015年至2019年间接受全面健康检查的70830例NAFLD患者的数据。根据纤维化-4（FIB-4）指数将患者分为三组：低（<1.30）、不确定（1.30-2.67）和高（>2.67）。我们评估了这些组之间MPV的差异，并分析了MPV与FIB-4指数之间的关联。
根据FIB-4指数分类的三组患者的MPV有显著差异（p<0.001）。此外，MPV与FIB-4指数之间存在微弱但具有统计学意义的正相关（rho = 0.170，p < 0.001）。对多个协变量进行调整的多变量线性回归显示，MPV与FIB-4指数仍有显著关联（β = 0.01，p < 0.001）。
MPV可作为评估NAFLD患者肝纤维化的一种补充性非侵入性标志物。需要进一步的研究来验证这些发现，并探索MPV与其他非侵入性标志物联合使用的效用。
