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本文引用的文献

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Broad Immunomodulatory Effects of the Dipeptidyl-peptidase-1 Inhibitor Brensocatib in Bronchiectasis: Data from the Phase 2, Double-Blind, Placebo-controlled WILLOW Trial.二肽基肽酶-1抑制剂布伦索卡特对支气管扩张症的广泛免疫调节作用：来自2期双盲、安慰剂对照的柳树试验的数据
Am J Respir Crit Care Med. 2025 Feb 12. doi: 10.1164/rccm.202408-1545OC.
2
What Changes in Research Focus Do We Need to Advance Care for Patients with Bronchiectasis?为推进支气管扩张症患者的护理，我们需要在研究重点上做出哪些改变？
Am J Respir Crit Care Med. 2024 Jul 1;210(1):22-23. doi: 10.1164/rccm.202403-0498VP.
3
The Precision Medicine Era of Bronchiectasis.支气管扩张症的精准医学时代
Am J Respir Crit Care Med. 2024 Jul 1;210(1):24-34. doi: 10.1164/rccm.202403-0473PP.
4
A Global Effort to Stop the Vicious Vortex: A Special Issue for World Bronchiectasis Day 2024.全球阻止恶性循环的努力：2024年世界支气管扩张症日特刊
Am J Respir Crit Care Med. 2024 Jul 1;210(1):1-3. doi: 10.1164/rccm.202405-0947ED.
5
Evaluation of high dose N- Acetylcysteine on airway inflammation and quality of life outcomes in adults with bronchiectasis: A randomised placebo-controlled pilot study.高剂量N-乙酰半胱氨酸对支气管扩张症成人气道炎症及生活质量结局的评估：一项随机安慰剂对照试验研究
Pulm Pharmacol Ther. 2024 Mar;84:102283. doi: 10.1016/j.pupt.2023.102283. Epub 2023 Dec 22.
6
The Mucin Gene Is Required for Normal Lung Function.粘蛋白基因是正常肺功能所必需的。
Am J Respir Crit Care Med. 2022 Apr 1;205(7):737-739. doi: 10.1164/rccm.202201-0064ED.
7
Mucus, Microbiomes and Pulmonary Disease.黏液、微生物群与肺部疾病
Biomedicines. 2021 Jun 13;9(6):675. doi: 10.3390/biomedicines9060675.
8
Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis.支气管扩张症中 DPP-1 抑制剂 Brensocatib 的 2 期临床试验。
N Engl J Med. 2020 Nov 26;383(22):2127-2137. doi: 10.1056/NEJMoa2021713. Epub 2020 Sep 7.
9
Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation.中性粒细胞衍生的α防御素通过抑制巨噬细胞mRNA翻译来控制炎症。
Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4350-5. doi: 10.1073/pnas.1601831113. Epub 2016 Apr 4.
10
Human defensins.人防御素
J Mol Med (Berl). 2005 Aug;83(8):587-95. doi: 10.1007/s00109-005-0657-1. Epub 2005 Apr 9.

Dancing With DPP-1: The Inflammatory Tango of Bronchiectasis.

作者信息

Waterer Grant W, Chotirmall Sanjay H

机构信息

University of Western Australia, Medicine, Perth, Western Australia, Australia.

Lee Kong Chian School of Medicine, Translational Respiratory Research Laboratory, Singapore, Singapore.

出版信息

Am J Respir Crit Care Med. 2025 Feb 18;211(5):678-9. doi: 10.1164/rccm.202501-0032ED.

DOI:10.1164/rccm.202501-0032ED
PMID:39965048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12091015/
Abstract
摘要