粘蛋白基因是正常肺功能所必需的。 - Suppr

Suppr

超能文献

The Mucin Gene Is Required for Normal Lung Function.

作者信息

Liegeois Maude A, Fahy John V

机构信息

Cardiovascular Research Institute University of California San Francisco San Francisco, California.

Cardiovascular Research Institute.

出版信息

Am J Respir Crit Care Med. 2022 Apr 1;205(7):737-739. doi: 10.1164/rccm.202201-0064ED.

DOI:10.1164/rccm.202201-0064ED

PMID:35148488

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9836220/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08e/9836220/818ad296dc74/rccm.202201-0064EDf1.jpg

相似文献

The Mucin Gene Is Required for Normal Lung Function.粘蛋白基因是正常肺功能所必需的。

Am J Respir Crit Care Med. 2022 Apr 1;205(7):737-739. doi: 10.1164/rccm.202201-0064ED.

[The expression of mucins gene in the human nasal polyps and allergic rhinitis].[黏蛋白基因在人鼻息肉和变应性鼻炎中的表达]

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Oct;23(20):923-5, 929.

Promoter analysis and aberrant expression of the MUC5B gene in diffuse panbronchiolitis.弥漫性泛细支气管炎中MUC5B基因的启动子分析及异常表达

Am J Respir Crit Care Med. 2005 May 1;171(9):949-57. doi: 10.1164/rccm.200409-1168OC. Epub 2005 Feb 11.

The Amount of MUC5B mucin in cervical mucus peaks at midcycle.宫颈黏液中MUC5B黏蛋白的含量在月经周期中期达到峰值。

J Clin Endocrinol Metab. 2001 Feb;86(2):594-600. doi: 10.1210/jcem.86.2.7174.

Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B.鉴定出一种主要的人类高分子量唾液粘蛋白（MG1）为气管支气管粘蛋白MUC5B。

Glycobiology. 1997 Apr;7(3):413-9. doi: 10.1093/glycob/7.3.413.

IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells.白细胞介素-8在转录后水平调节肺上皮细胞中的黏蛋白基因表达。

J Immunol. 2009 Aug 1;183(3):2159-66. doi: 10.4049/jimmunol.0803022. Epub 2009 Jul 13.

Evolutionary history of the 11p15 human mucin gene family.人类11p15粘蛋白基因家族的进化史。

J Mol Evol. 1998 Jan;46(1):102-6. doi: 10.1007/pl00006276.

Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region.人黏蛋白5B基因在气道上皮中的表达特征以及氨基末端和5'侧翼区域的基因组克隆

Am J Respir Cell Mol Biol. 2001 Nov;25(5):542-53. doi: 10.1165/ajrcmb.25.5.4298.

Characterization of mucins from cultured normal human tracheobronchial epithelial cells.培养的正常人气管支气管上皮细胞中黏蛋白的特性分析。

Am J Physiol Lung Cell Mol Physiol. 2000 Jun;278(6):L1118-28. doi: 10.1152/ajplung.2000.278.6.L1118.

Human mucin genes: genomic organization and expression of MUC4, MUC5AC and MUC5B.人类黏蛋白基因：MUC4、MUC5AC和MUC5B的基因组结构与表达

Biochem Soc Trans. 1995 Nov;23(4):800-5. doi: 10.1042/bst0230800.

引用本文的文献

The multifaceted roles of mucins family in lung cancer: from prognostic biomarkers to promising targets.黏蛋白家族在肺癌中的多方面作用：从预后生物标志物到有前景的靶点。

Front Immunol. 2025 Jun 27;16:1608140. doi: 10.3389/fimmu.2025.1608140. eCollection 2025.

Dancing With DPP-1: The Inflammatory Tango of Bronchiectasis.与二肽基肽酶-1共舞：支气管扩张症的炎性探戈

Am J Respir Crit Care Med. 2025 Feb 18;211(5):678-9. doi: 10.1164/rccm.202501-0032ED.

Salivary diagnostics: opportunities and challenges.唾液诊断：机遇与挑战。

Theranostics. 2024 Oct 21;14(18):6969-6990. doi: 10.7150/thno.100600. eCollection 2024.

Lung regeneration: diverse cell types and the therapeutic potential.肺再生：多种细胞类型及其治疗潜力。

MedComm (2020). 2024 Feb 23;5(2):e494. doi: 10.1002/mco2.494. eCollection 2024 Feb.

Toxicological assessment of E-cigarette flavored E-liquids aerosols using Calu-3 cells: A 3D lung model approach.使用 Calu-3 细胞对电子烟调味电子烟液气溶胶的毒理学评估：一种 3D 肺模型方法。

Toxicology. 2023 Dec;500:153683. doi: 10.1016/j.tox.2023.153683. Epub 2023 Nov 25.

Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells.雾化薄荷醇通过原发性气道上皮细胞中的 TRPM8 和 MUC5AC/MUC5B 损害纤毛清除功能。

Int J Mol Sci. 2023 Jan 15;24(2):1694. doi: 10.3390/ijms24021694.

本文引用的文献

Hereditary Mucin Deficiency Caused by Biallelic Loss of Function of .遗传性黏蛋白缺乏症由. 的双等位基因功能丧失引起。

Am J Respir Crit Care Med. 2022 Apr 1;205(7):761-768. doi: 10.1164/rccm.202106-1456OC.

Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B.黏蛋白 MUC5AC N 端区域的组装和组织：与 MUC5B 在结构和功能上区别的指示。

Proc Natl Acad Sci U S A. 2021 Sep 28;118(39). doi: 10.1073/pnas.2104490118.

Lack of airway submucosal glands impairs respiratory host defenses.呼吸道黏膜下腺体缺失会损害呼吸道宿主防御功能。

Elife. 2020 Oct 7;9:e59653. doi: 10.7554/eLife.59653.

Mucus strands from submucosal glands initiate mucociliary transport of large particles.来自黏膜下腺的黏液丝启动大颗粒的黏液纤毛转运。

JCI Insight. 2019 Jan 10;4(1):e124863. doi: 10.1172/jci.insight.124863.

Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.正常/健康人体气道中分泌型黏蛋白 MUC5AC 和 MUC5B 的定位。

Am J Respir Crit Care Med. 2019 Mar 15;199(6):715-727. doi: 10.1164/rccm.201804-0734OC.

Gel-forming mucins form distinct morphologic structures in airways.胶样黏蛋白在气道中形成独特的形态结构。

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6842-6847. doi: 10.1073/pnas.1703228114. Epub 2017 Jun 12.

Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.哮喘患者气道黏液中MUC5AC和MUC5B蛋白的异常

Am J Respir Crit Care Med. 2016 Nov 15;194(10):1296-1299. doi: 10.1164/rccm.201603-0526LE.

Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma.富含MUC5AC的黏液的上皮栓系会损害哮喘中的黏液纤毛运输。

J Clin Invest. 2016 Jun 1;126(6):2367-71. doi: 10.1172/JCI84910. Epub 2016 May 16.

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.聚合黏蛋白Muc5ac是过敏性气道高反应性所必需的。

Nat Commun. 2015 Feb 17;6:6281. doi: 10.1038/ncomms7281.

Salivary mucins protect surfaces from colonization by cariogenic bacteria.唾液黏蛋白可保护表面免受致龋菌的定植。

Appl Environ Microbiol. 2015 Jan;81(1):332-8. doi: 10.1128/AEM.02573-14. Epub 2014 Oct 24.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验