粘蛋白基因是正常肺功能所必需的。 - Suppr

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The Mucin Gene Is Required for Normal Lung Function.

作者信息

Liegeois Maude A, Fahy John V

机构信息

Cardiovascular Research Institute University of California San Francisco San Francisco, California.

Cardiovascular Research Institute.

出版信息

Am J Respir Crit Care Med. 2022 Apr 1;205(7):737-739. doi: 10.1164/rccm.202201-0064ED.

DOI:10.1164/rccm.202201-0064ED

PMID:35148488

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9836220/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c08e/9836220/818ad296dc74/rccm.202201-0064EDf1.jpg

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The Mucin Gene Is Required for Normal Lung Function.

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Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B.

Proc Natl Acad Sci U S A. 2021 Sep 28;118(39). doi: 10.1073/pnas.2104490118.

Lack of airway submucosal glands impairs respiratory host defenses.

Elife. 2020 Oct 7;9:e59653. doi: 10.7554/eLife.59653.

Mucus strands from submucosal glands initiate mucociliary transport of large particles.

JCI Insight. 2019 Jan 10;4(1):e124863. doi: 10.1172/jci.insight.124863.

Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.

Am J Respir Crit Care Med. 2019 Mar 15;199(6):715-727. doi: 10.1164/rccm.201804-0734OC.

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Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6842-6847. doi: 10.1073/pnas.1703228114. Epub 2017 Jun 12.

Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.

Am J Respir Crit Care Med. 2016 Nov 15;194(10):1296-1299. doi: 10.1164/rccm.201603-0526LE.

Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma.

J Clin Invest. 2016 Jun 1;126(6):2367-71. doi: 10.1172/JCI84910. Epub 2016 May 16.

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.

Nat Commun. 2015 Feb 17;6:6281. doi: 10.1038/ncomms7281.

Salivary mucins protect surfaces from colonization by cariogenic bacteria.

Appl Environ Microbiol. 2015 Jan;81(1):332-8. doi: 10.1128/AEM.02573-14. Epub 2014 Oct 24.

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相似文献

The Mucin Gene Is Required for Normal Lung Function.

Am J Respir Crit Care Med. 2022 Apr 1;205(7):737-739. doi: 10.1164/rccm.202201-0064ED.

[The expression of mucins gene in the human nasal polyps and allergic rhinitis].

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Oct;23(20):923-5, 929.

Promoter analysis and aberrant expression of the MUC5B gene in diffuse panbronchiolitis.

Am J Respir Crit Care Med. 2005 May 1;171(9):949-57. doi: 10.1164/rccm.200409-1168OC. Epub 2005 Feb 11.

The Amount of MUC5B mucin in cervical mucus peaks at midcycle.

J Clin Endocrinol Metab. 2001 Feb;86(2):594-600. doi: 10.1210/jcem.86.2.7174.

Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B.

Glycobiology. 1997 Apr;7(3):413-9. doi: 10.1093/glycob/7.3.413.

IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells.

J Immunol. 2009 Aug 1;183(3):2159-66. doi: 10.4049/jimmunol.0803022. Epub 2009 Jul 13.

Evolutionary history of the 11p15 human mucin gene family.

J Mol Evol. 1998 Jan;46(1):102-6. doi: 10.1007/pl00006276.

Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region.

Am J Respir Cell Mol Biol. 2001 Nov;25(5):542-53. doi: 10.1165/ajrcmb.25.5.4298.

Characterization of mucins from cultured normal human tracheobronchial epithelial cells.

Am J Physiol Lung Cell Mol Physiol. 2000 Jun;278(6):L1118-28. doi: 10.1152/ajplung.2000.278.6.L1118.

Human mucin genes: genomic organization and expression of MUC4, MUC5AC and MUC5B.

Biochem Soc Trans. 1995 Nov;23(4):800-5. doi: 10.1042/bst0230800.

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Int J Mol Sci. 2023 Jan 15;24(2):1694. doi: 10.3390/ijms24021694.

本文引用的文献

Hereditary Mucin Deficiency Caused by Biallelic Loss of Function of .

Am J Respir Crit Care Med. 2022 Apr 1;205(7):761-768. doi: 10.1164/rccm.202106-1456OC.

Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B.

Proc Natl Acad Sci U S A. 2021 Sep 28;118(39). doi: 10.1073/pnas.2104490118.

Lack of airway submucosal glands impairs respiratory host defenses.

Elife. 2020 Oct 7;9:e59653. doi: 10.7554/eLife.59653.

Mucus strands from submucosal glands initiate mucociliary transport of large particles.

JCI Insight. 2019 Jan 10;4(1):e124863. doi: 10.1172/jci.insight.124863.

Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.

Am J Respir Crit Care Med. 2019 Mar 15;199(6):715-727. doi: 10.1164/rccm.201804-0734OC.

Gel-forming mucins form distinct morphologic structures in airways.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6842-6847. doi: 10.1073/pnas.1703228114. Epub 2017 Jun 12.

Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.

Am J Respir Crit Care Med. 2016 Nov 15;194(10):1296-1299. doi: 10.1164/rccm.201603-0526LE.

Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma.

J Clin Invest. 2016 Jun 1;126(6):2367-71. doi: 10.1172/JCI84910. Epub 2016 May 16.

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.

Nat Commun. 2015 Feb 17;6:6281. doi: 10.1038/ncomms7281.

Salivary mucins protect surfaces from colonization by cariogenic bacteria.

Appl Environ Microbiol. 2015 Jan;81(1):332-8. doi: 10.1128/AEM.02573-14. Epub 2014 Oct 24.