Galbiati Francesca, Plessow Franziska, Plummer Lacey, Campbell Mark B, Nazarloo Shawn, Carter C Sue, Carroll Rona S, Kim Han K, Pereira Sidney A, Paulis Daria, Davis John M, Miller Karen K, Kaiser Ursula B, Seminara Stephanie B, Aulinas Anna, Lawson Elizabeth A
Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States.
Faculty of Medicine, University of Vic/Central University of Catalonia (UVIC/UCC), Vic 08500, Spain.
Eur J Endocrinol. 2025 Mar 3;192(3):K24-K29. doi: 10.1093/ejendo/lvaf001.
A clinically significant oxytocin-deficient state (OXT-D) has been established in adults with arginine vasopressin deficiency, and there is a need to develop diagnostic testing. Kisspeptin (KP) is a candidate for such a test, as KP receptors are found on oxytocinergic neurons, and KP administration increases plasma OXT in animals. We hypothesized that intravenous KP administration would increase peripheral OXT levels post-injection in healthy adults.
Kisspeptin-112-121 (KP analog, 0.24 nmol/kg bolus) was administered to 12 healthy adults (50% female). Serum OXT was measured before and 10, 20, 40, and 60 min after KP administration.
Males and females did not differ significantly in age, BMI, or baseline OXT levels. Ten minutes after KP, OXT increased by 18.8% from baseline (FDR-P = .004) with a greater increase in males than females (31.9% vs 5.7%, respectively, FDR-P = .004).
Our data support KP as a candidate for a provocative test to identify OXT-D in males.
Our study was registered on ClinicalTrials.gov (NCT00914823).
在患有精氨酸加压素缺乏症的成年人中已证实存在具有临床意义的催产素缺乏状态（OXT-D），因此需要开发诊断测试方法。 kisspeptin（KP）是此类测试的一个候选物质，因为在催产素能神经元上发现了KP受体，并且在动物体内注射KP会增加血浆催产素水平。我们假设，对健康成年人静脉注射KP会在注射后提高外周催产素水平。
对12名健康成年人（50%为女性）静脉注射kisspeptin-112-121（KP类似物，0.24 nmol/kg推注剂量）。在注射KP前以及注射后10、20、40和60分钟测量血清催产素水平。
男性和女性在年龄、体重指数或基线催产素水平方面无显著差异。注射KP后10分钟，催产素水平较基线升高了18.8%（FDR-P = .004），男性升高幅度大于女性（分别为31.9%和5.7%，FDR-P = .004）。
我们的数据支持将KP作为一种激发试验的候选物质，用于识别男性的OXT-D。
我们的研究已在ClinicalTrials.gov上注册（NCT00914823）。
