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与选择性雄激素受体调节剂相关的自我报告的副作用:社交媒体数据分析

Self-Reported Side Effects Associated With Selective Androgen Receptor Modulators: Social Media Data Analysis.

作者信息

Joshi Aditya, Kaune Diego Federico, Leff Phillip, Fraser Emily, Lee Sarah, Harrison Morgan, Hazin Moustafa

机构信息

Department of Internal Medicine, Phoenix Health Sciences Campus, Creighton University School of Medicine, Phoenix, AZ, United States.

Johns Hopkins University, Baltimore, MD, United States.

出版信息

J Med Internet Res. 2025 Feb 18;27:e65031. doi: 10.2196/65031.

DOI:10.2196/65031
PMID:39965201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11888096/
Abstract

This study focuses on the prevalence and dangers of selective androgen receptor modulator use through a social media (Reddit) analysis. Physicians should be aware that patients are increasingly seeking medical advice through social media, and adverse events are likely underreported in the literature.

摘要

本研究通过社交媒体(Reddit)分析,聚焦于选择性雄激素受体调节剂使用的普遍性及风险。医生应意识到,患者越来越多地通过社交媒体寻求医疗建议,且文献中不良事件可能报告不足。

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Self-Reported Side Effects Associated With Selective Androgen Receptor Modulators: Social Media Data Analysis.与选择性雄激素受体调节剂相关的自我报告的副作用:社交媒体数据分析
J Med Internet Res. 2025 Feb 18;27:e65031. doi: 10.2196/65031.
2
Considerations, possible contraindications, and potential mechanisms for deleterious effect in recreational and athletic use of selective androgen receptor modulators (SARMs) in lieu of anabolic androgenic steroids: A narrative review.在娱乐和运动中使用选择性雄激素受体调节剂(SARMs)代替合成代谢雄激素类固醇时的考虑因素、可能的禁忌症和潜在的有害作用机制:叙述性综述。
Steroids. 2020 Dec;164:108753. doi: 10.1016/j.steroids.2020.108753. Epub 2020 Oct 24.
3
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Steroidal androgens and nonsteroidal, tissue-selective androgen receptor modulator, S-22, regulate androgen receptor function through distinct genomic and nongenomic signaling pathways.甾体雄激素和非甾体类、组织选择性雄激素受体调节剂S-22通过不同的基因组和非基因组信号通路调节雄激素受体功能。
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本文引用的文献

1
Selective Androgen Receptor Modulators-Transformative Drugs or Heralds of the Next Drug Epidemic?选择性雄激素受体调节剂——变革性药物还是下一场药物流行的先驱?
JAMA. 2024 Apr 23;331(16):1359-1360. doi: 10.1001/jama.2024.1769.
2
Androgen Receptor and Cardiovascular Disease: A Potential Risk for the Abuse of Supplements Containing Selective Androgen Receptor Modulators.雄激素受体与心血管疾病:滥用含选择性雄激素受体调节剂的补充剂的潜在风险。
Nutrients. 2023 Jul 26;15(15):3330. doi: 10.3390/nu15153330.
3
Systematic Review of Safety of Selective Androgen Receptor Modulators in Healthy Adults: Implications for Recreational Users.
健康成年人中选择性雄激素受体调节剂安全性的系统评价:对娱乐性使用者的启示。
J Xenobiot. 2023 May 10;13(2):218-236. doi: 10.3390/jox13020017.
4
Selective Androgen Receptor Modulators (SARMs)-Induced Liver Injury: A Case Report and Review of Literature.选择性雄激素受体调节剂(SARMs)所致肝损伤:一例报告及文献复习
Cureus. 2023 Feb 17;15(2):e35094. doi: 10.7759/cureus.35094. eCollection 2023 Feb.
5
Selective Androgen Receptor Modulators: An Emerging Liver Toxin.选择性雄激素受体调节剂:一种新兴的肝毒素。
J Clin Transl Hepatol. 2023 Feb 28;11(1):188-196. doi: 10.14218/JCTH.2022.00207. Epub 2022 Nov 4.
6
Adverse effects and potential benefits among selective androgen receptor modulators users: a cross-sectional survey.选择性雄激素受体调节剂使用者的不良反应和潜在益处:一项横断面调查。
Int J Impot Res. 2022 Dec;34(8):757-761. doi: 10.1038/s41443-021-00465-0. Epub 2021 Sep 1.
7
Selective androgen receptor modulators (SARMs): a novel approach to androgen therapy for the new millennium.选择性雄激素受体调节剂(SARMs):新千年雄激素治疗的新方法。
J Clin Endocrinol Metab. 1999 Oct;84(10):3459-62. doi: 10.1210/jcem.84.10.6122.