[哈曼对安定抗焦虑作用的诱导性改变]
[Harman-induced changes in the anxiolytic effect of diazepam].
作者信息
Zin'kovskaia L Ia, Dolzhenko A T, Komissarov I V
出版信息
Farmakol Toksikol. 1985 Mar-Apr;48(2):21-3.
PMID:3996567
Abstract
It has been demonstrated in experiments on rats under conflict situation that intraperitoneal injection of harman in high doses (20 mg/kg) counteracts and, in low doses (1 mg/kg), potentiates the anxiolytic effect of diazepam. A possible mechanism of the dual effect of harman on the anxiolytic action of diazepam is discussed.
摘要
在冲突情境下对大鼠进行的实验表明，腹腔注射高剂量（20毫克/千克）的哈尔满会抵消地西泮的抗焦虑作用，而低剂量（1毫克/千克）则会增强地西泮的抗焦虑作用。文中讨论了哈尔满对地西泮抗焦虑作用产生双重效应的可能机制。
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