Strelianaia E I, Voloshin P V, Bozhko G Kh
Farmakol Toksikol. 1985 Mar-Apr;48(2):86-9.
It has been shown by gel chromatography and electrophoresis in polyacrylamide gel that single and chronic therapeutic doses of furosemide and hypothiazide did not alter the structure of rat blood serum proteins. Exception was a single administration of hypothiazide that provoked the formation of labile protein associations. In contrast, administration of urea to the animals resulted in the formation of large stable aggregations of serum proteins. The associations contained albumin, transferrin, immunoglobulins and group-specific proteins situated on the electrophoregram between transferrin and albumin.
凝胶色谱法和聚丙烯酰胺凝胶电泳结果表明，单次及长期治疗剂量的呋塞米和氢氯噻嗪均未改变大鼠血清蛋白的结构。单次给予氢氯噻嗪是个例外，它引发了不稳定蛋白质缔合物的形成。相比之下，给动物注射尿素导致血清蛋白形成大的稳定聚集体。这些缔合物包含白蛋白、转铁蛋白、免疫球蛋白以及位于转铁蛋白和白蛋白之间电泳图谱上的组特异性蛋白。
