3-羟基酰基辅酶A表异构酶是一种过氧化物酶体酶，因此不参与线粒体脂肪酸氧化。
3-Hydroxyacyl-CoA epimerase is a peroxisomal enzyme and therefore not involved in mitochondrial fatty acid oxidation.
作者信息
Chu C H, Schulz H
出版信息
FEBS Lett. 1985 Jun 3;185(1):129-34. doi: 10.1016/0014-5793(85)80755-9.
PMID:3996591
Abstract
The subcellular location of 3-hydroxyacyl-CoA epimerase (EC 5.1.2.3) was studied by differential centrifugation and Percoll density gradient centrifugation of a rat liver homogenate. The enzyme was found to be associated with peroxisomes but not with mitochondria. This observation proves that 3-hydroxy-acyl-CoA epimerase does not function in mitochondrial beta-oxidation of polyunsaturated fatty acids which are degraded by a modified pathway.
摘要
通过对大鼠肝脏匀浆进行差速离心和Percoll密度梯度离心，研究了3-羟酰基辅酶A表异构酶（EC 5.1.2.3）的亚细胞定位。发现该酶与过氧化物酶体相关，而与线粒体无关。这一观察结果证明，3-羟酰基辅酶A表异构酶在多不饱和脂肪酸的线粒体β-氧化中不起作用，多不饱和脂肪酸通过一种改良途径进行降解。
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