过氧化氢在人类血小板聚集中起作用。
Hydrogen peroxide has a role in the aggregation of human platelets.
作者信息
Del Principe D, Menichelli A, De Matteis W, Di Corpo M L, Di Giulio S, Finazzi-Agro A
出版信息
FEBS Lett. 1985 Jun 3;185(1):142-6. doi: 10.1016/0014-5793(85)80758-4.
The aggregation of platelets induced by soluble and particulate stimuli is enhanced by the addition of minute amounts of H2O2. Externally added catalase strongly inhibits the aggregation induced by particulate stimuli and by phorbol myristate acetate (PMA). The addition of aminotriazole to stimulated platelets causes a significant inhibition of intracellular catalase. This indicates the formation of H2O2 inside the platelets during activation. No effects were observed when the platelets were stimulated by the ionophore A23187.
可溶性和颗粒性刺激物诱导的血小板聚集可因添加微量过氧化氢而增强。外部添加的过氧化氢酶可强烈抑制颗粒性刺激物和佛波酯（PMA）诱导的聚集。向受刺激的血小板中添加氨基三唑会导致细胞内过氧化氢酶受到显著抑制。这表明血小板在激活过程中会在内部形成过氧化氢。当血小板受到离子载体A23187刺激时未观察到任何影响。
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