Widness J A, Cowett R M, Coustan D R, Carpenter M W, Oh W
Diabetes. 1985 Jun;34 Suppl 2:61-5. doi: 10.2337/diab.34.2.s61.
Of 1839 pregnant women screened prospectively, 52 were identified to have glucose intolerance. Ten additional pregnant women identified as having glucose intolerance before the universal screening were also included in the study cohort. These 62 patients were followed in a perinatal high-risk clinic with weekly plasma glucose determinations. The patients were treated with diet and, in addition, 21 of 62 were treated with insulin therapeutically. By observational cohort design, the infants and a comparable number of matched controls were evaluated for evidence of neonatal morbidities and classified into percentile for birth weight. Compared with the control group, the operative mode of delivery, the mean birth weight, the birth-weight percentile, the male/female ratio, the frequency of low Apgar score (less than or equal to 6 at 1 min), and the number of infants with congenital anomalies were significantly higher in the infants born to the glucose-intolerant mothers. Although the mean maternal blood sugar was maintained within a reasonably euglycemic range, the usual neonatal morbidities were not eliminated entirely. Further understanding and management of glucose intolerance in pregnancy is necessary to further diminish or eliminate neonatal morbidities.
在对1839名孕妇进行前瞻性筛查时，发现有52名孕妇存在糖耐量异常。另外，在进行普遍筛查之前被确定为糖耐量异常的10名孕妇也被纳入研究队列。这62名患者在围产期高危诊所接受随访，每周测定血浆葡萄糖水平。患者接受饮食治疗，此外，62名患者中有21名接受了胰岛素治疗。通过观察性队列设计，对婴儿及数量相当的匹配对照进行新生儿发病情况评估，并将出生体重按百分位数分类。与对照组相比，糖耐量异常母亲所生婴儿的分娩手术方式、平均出生体重、出生体重百分位数、男/女比例、低Apgar评分（1分钟时小于或等于6分）的频率以及先天性异常婴儿的数量均显著更高。尽管母亲的平均血糖维持在合理的正常血糖范围内，但常见的新生儿发病情况并未完全消除。有必要进一步了解和管理孕期糖耐量异常，以进一步减少或消除新生儿发病情况。
