Artal R, Golde S H, Dorey F, McClellan S N, Gratacos J, Lirette T, Montoro M, Wu P Y, Anderson B, Mestman J
Am J Obstet Gynecol. 1983 Nov 1;147(5):537-41. doi: 10.1016/0002-9378(83)90012-1.
Maternal glucose variability was studied in 154 pregnant diabetic patients hospitalized during the last month of their pregnancies. By means of several statistical analyses of the coefficient of variation for within-day plasma glucose variability, we found as follows. (1) There was a significant association between maternal glucose variability and neonatal outcome. (2) Patients with greater glucose variability had more episodes of hyperglycemia, but not hypoglycemia. (3) There was no correlation between maternal glucose variability and the birth weight of the infant. We are proposing the use of an index for glucose variability to monitor glucose control in pregnancy and predict neonatal outcome. Although absence of glucose variability will not ensure prevention of neonatal complications, there is a clear association between greater glucose variability and neonatal complications.
对154名在妊娠最后一个月住院的糖尿病孕妇的母体血糖变异性进行了研究。通过对日内血浆葡萄糖变异性变异系数的几种统计分析，我们发现如下：（1）母体血糖变异性与新生儿结局之间存在显著关联。（2）血糖变异性较大的患者高血糖发作次数更多，但低血糖发作次数并非如此。（3）母体血糖变异性与婴儿出生体重之间无相关性。我们建议使用血糖变异性指数来监测孕期血糖控制并预测新生儿结局。虽然不存在血糖变异性并不能确保预防新生儿并发症，但血糖变异性较大与新生儿并发症之间存在明确关联。
