Alves Samuel de Mattos, Lisboa-Filho Paulo Noronha, Zilli Vieira Carolina Letícia, Piacenti-Silva Marina
Institute of Biosciences of Botucatu, Campus Botucatu, São Paulo State University (UNESP), Botucatu, SP, Brazil.
School of Sciences, Campus Bauru, São Paulo State University (UNESP), Bauru, SP, Brazil.
Front Neurosci. 2025 Feb 4;19:1543826. doi: 10.3389/fnins.2025.1543826. eCollection 2025.
Research indicates that by 2050, more than 150 million people will be living with Alzheimer's disease (AD), a condition associated with neurodegeneration due to the accumulation of amyloid-beta and tau proteins. In addition to genetic background, endocrine disruption, and cellular senescence, management of the gut microbiota has emerged as a key element in the diagnosis, progression, and treatment of AD, as certain bacterial metabolites can travel through the bloodstream and cross the blood-brain barrier. This mini-review explores the relationship between tau protein accumulation and gut dysbiosis in . This model facilitates the investigation of how gut-derived metabolites contribute to neurocognitive impairment and dementia. Understanding the role of direct and indirect bacterial by-products, such as lactate and acetate, in glial cell activation and tau protein dynamics may provide insights into the mechanisms of AD progression and contribute to more effective treatments. Here we discuss how the simplicity and extensive genetic tools of make it a valuable model for studying these interactions and testing potential therapeutics, including probiotics. Integrating studies with other established models may reveal conserved pathways and accelerate the translation of findings into clinical applications.
研究表明，到2050年，将有超过1.5亿人患有阿尔茨海默病（AD），这是一种由于β-淀粉样蛋白和tau蛋白积累而导致神经退行性变的疾病。除了遗传背景、内分泌干扰和细胞衰老外，肠道微生物群的管理已成为AD诊断、进展和治疗的关键因素，因为某些细菌代谢产物可以通过血液循环并穿过血脑屏障。这篇小型综述探讨了tau蛋白积累与肠道菌群失调之间的关系。该模型有助于研究肠道衍生代谢产物如何导致神经认知障碍和痴呆。了解直接和间接细菌副产物（如乳酸和乙酸盐）在胶质细胞活化和tau蛋白动态变化中的作用，可能会为AD进展机制提供见解，并有助于开发更有效的治疗方法。在这里，我们讨论了[具体模型名称]的简单性和广泛的遗传工具如何使其成为研究这些相互作用和测试潜在治疗方法（包括益生菌）的有价值模型。将[具体模型名称]研究与其他已建立的模型相结合，可能会揭示保守途径，并加速研究结果转化为临床应用。
