Suppr超能文献

新诊断2型糖尿病患者中偶然发现的慢性肾脏病的患病率及相关因素

Prevalence of and Factors Associated With Incidental Chronic Kidney Disease in Patients Newly Diagnosed With Type 2 Diabetes Mellitus.

作者信息

Alidrisi Duha A, Alidrisi Haider A, Reman Khulood A, Hadi Ali M

机构信息

Clinical Pharmacy, College of Pharmacy, University of Basrah, Basrah, IRQ.

Diabetes and Endocrinology, Faiha Specialized Diabetes, Endocrine, and Metabolism Center, Basrah, IRQ.

出版信息

Cureus. 2025 Feb 18;17(2):e79235. doi: 10.7759/cureus.79235. eCollection 2025 Feb.

Abstract

OBJECTIVE

The objective of this study was to detect the prevalence of incidental chronic kidney disease (CKD) in patients newly diagnosed with type 2 diabetes (T2D).

METHOD

This was a cross-sectional study conducted from July 2023 to November 2024, at Faiha Specialized Diabetes, Endocrine, and Metabolism Center and Al-Rafidain Specialized Center in Basrah, southern Iraq. A total of 202 newly diagnosed drug-naïve T2D patients were included. The baseline clinical and biochemical characteristics for the patients at inclusion. CKD was diagnosed by measuring the estimated glomerular filtration rate (eGFR) and urine albumin creatinine ratio (UACR).

RESULTS

The mean age of patients included in the study was 49.1±12 years. CKD was diagnosed in 68 (33.7%) patients based on GFR <60 mL/minute/1.73 m and/or UACR ≥ 30 mg/g. The CKD categories G1, 2, G3a, and 3b were prevalent in 71.3%, 24.2%, 3.0%, and 1.5%, respectively. For albuminuria, 31.2% had UACR 10-30 mg/g, 22.8% had UACR 30-300 mg/g, and 7.9% had UACR higher than 300 mg/g. A stepwise binary regression analysis showed that higher patients' age and HbA1c levels were the factors that were significantly associated with CKD.

CONCLUSION

incidental CKD is prevalent in one-third of the newly diagnosed T2D. Early screening for CKD is highly recommended as it will affect overall management.

摘要

目的

本研究的目的是检测新诊断的2型糖尿病(T2D)患者中偶发性慢性肾脏病(CKD)的患病率。

方法

这是一项横断面研究,于2023年7月至2024年11月在伊拉克南部巴士拉的法伊哈糖尿病、内分泌和代谢专科医院及拉菲丹专科医院进行。共纳入202例新诊断的未接受过药物治疗的T2D患者。记录患者纳入时的基线临床和生化特征。通过测量估算肾小球滤过率(eGFR)和尿白蛋白肌酐比值(UACR)来诊断CKD。

结果

纳入研究的患者平均年龄为49.1±12岁。根据肾小球滤过率(GFR)<60 mL/分钟/1.73 m²和/或尿白蛋白肌酐比值(UACR)≥30 mg/g,68例(33.7%)患者被诊断为CKD。CKD的G1、G2、G3a和G3b期患病率分别为71.3%、24.2%、3.0%和1.5%。对于蛋白尿,31.2%的患者尿白蛋白肌酐比值为10 - 30 mg/g,22.8%的患者尿白蛋白肌酐比值为30 - 300 mg/g,7.9%的患者尿白蛋白肌酐比值高于300 mg/g。逐步二元回归分析显示,患者年龄较大和糖化血红蛋白(HbA1c)水平较高是与CKD显著相关的因素。

结论

新诊断的T2D患者中有三分之一存在偶发性CKD。强烈建议对CKD进行早期筛查,因为这将影响整体治疗管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e66b/11835198/d64d54ad5b9e/cureus-0017-00000079235-i01.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验