Kartlasmis Kezban, Cakir Gungor Ayse Nur, Kuyucu Yurdun, Kara Samet
Institute of Health Sciences, Cukurova University, Adana,Turkey.
Adanus Women's Health Research Group, Cukurova University, Adana,Turkey.
Arch Med Sci. 2024 Dec 13;20(6):1793-1796. doi: 10.5114/aoms/184349. eCollection 2024.
The use of chemotherapeutic agents during childhood, adolescence, and early adulthood has a detrimental effect on ovarian functions, leading to a decrease in ovarian reserves, thus adversely affecting fertility. Alkylating agents are one of the most frequently used groups of chemotherapeutics in this age group. An important and effective chemotherapeutic drug, procarbazine is used to treat brain tumors and Hodgkin lymphoma in children, adolescents, and young adults. This agent is also an indispensable component of combination-type chemotherapy. Procarbazine has a detrimental impact on ovarian reserve by directly targeting the oocyte or indirectly through somatic cell destruction. Evidence gathered thus far indicates that procarbazine's mode of action in the ovaries may involve apoptosis, inflammation, and oxidative stress. This review seeks to clarify the processes by which procarbazine might induce apoptosis, inflammation, and oxidative stress, hence affecting ovarian reserve and functioning.
在儿童期、青少年期和成年早期使用化疗药物会对卵巢功能产生不利影响，导致卵巢储备减少，进而对生育能力产生负面影响。烷化剂是该年龄组中最常用的化疗药物类别之一。丙卡巴肼是一种重要且有效的化疗药物，用于治疗儿童、青少年和年轻成年人的脑肿瘤和霍奇金淋巴瘤。该药物也是联合化疗中不可或缺的组成部分。丙卡巴肼通过直接靶向卵母细胞或间接通过体细胞破坏对卵巢储备产生不利影响。迄今为止收集的证据表明，丙卡巴肼在卵巢中的作用方式可能涉及细胞凋亡、炎症和氧化应激。本综述旨在阐明丙卡巴肼可能诱导细胞凋亡、炎症和氧化应激，从而影响卵巢储备和功能的过程。
