Kiratli Kazim, Kahraman Hazan Gul, Guven Yusuf Ziya, Akay Fahrettin, Aysin Murat
Department of Infectious Diseases and Clinical Microbiology, Katip Celebi University Ataturk Educating and Research Hospital, Izmir 35360, Türkiye.
Department of Ophthalmology, Democracy University Buca Seyfi Demirsoy Educating and Research Hospital, Izmir 35390, Türkiye.
Int J Ophthalmol. 2025 Feb 18;18(2):283-289. doi: 10.18240/ijo.2025.02.12. eCollection 2025.
To examine the subclinical alterations in the retina and choroid between patients with 2019 coronavirus disease (COVID-19)-related lung involvement and the healthy control group.
In this prospective case-control study, 85 cases with lung involvement due to COVID-19 and 50 healthy cases were included. Best-corrected visual acuity, intraocular pressure measurement, and anterior and posterior segment examination were performed on both eyes for each individual. Choroidal and retinal changes were examined and recorded by optical coherence tomography angiography.
All choroidal thickness measurements of the COVID-19 group showed no statistically significant difference when compared to healthy individuals. When vascular density and perfusion density values were compared, there was a decrease in the average of these values in the COVID-19 group, although it was not statistically significant (=0.088, =0.065 respectively). When the fovea avascular zone (FAZ) area values were compared, the average was 0.57±0.38 in the COVID-19 group, while it was 0.54±0.24 in the control group.
Although our data are not statistically significant, the decrease in vascularity and perfusion and the accompanying FAZ expansion are detected in the acute period (1 month). These changes may anatomically alter the retina in the long term and affect functional vision. Future ischemia-related alterations in the retina caused by a prior COVID-19 infection may arise in situations without comorbidities and may require concern in the patient's systemic assessment.
研究2019冠状病毒病（COVID-19）相关肺部受累患者与健康对照组之间视网膜和脉络膜的亚临床改变。
在这项前瞻性病例对照研究中，纳入了85例因COVID-19导致肺部受累的病例和50例健康病例。对每个个体的双眼进行最佳矫正视力、眼压测量以及眼前段和眼后段检查。通过光学相干断层扫描血管造影检查并记录脉络膜和视网膜的变化。
与健康个体相比，COVID-19组的所有脉络膜厚度测量值均无统计学显著差异。比较血管密度和灌注密度值时，COVID-19组这些值的平均值有所下降，尽管无统计学显著性（分别为=0.088，=0.065）。比较中心凹无血管区（FAZ）面积值时，COVID-19组的平均值为0.57±0.38，而对照组为0.54±0.24。
尽管我们的数据无统计学显著性，但在急性期（1个月）检测到血管形成和灌注减少以及伴随的FAZ扩大。这些变化可能会在长期内从解剖学上改变视网膜并影响功能性视力。先前COVID-19感染引起的视网膜未来与缺血相关的改变可能在无合并症的情况下出现，并且在患者的全身评估中可能需要关注。
