Wang Xiaoli, Wei Nan, Yang Huizhen, Wang Xiaoyan, Zhang Xiaoju, Zhang Qianqian
Department of Respiratory and Critical Care Medicine, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Henan International Joint Laboratory of Diagnosis and Treatment for Pulmonary Nodules, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Front Oncol. 2025 Feb 4;15:1487334. doi: 10.3389/fonc.2025.1487334. eCollection 2025.
Alpha-fetoprotein (AFP)-producing hepatoid adenocarcinoma of lung (HAL) is a rare type of lung cancer, with its characteristics being not yet fully clarified. We recently encountered a case of HAL combined with idiopathic pulmonary fibrosis (IPF), which has never been reported.
A 66-year-old man consulted our hospital with a chief complaint of cough. Chest computed tomography (CT) revealed multiple nodules measuring from 8mm to 20mm in diameter located in bilateral lung, along with an enlarged left hilar lymph node. CT-guided percutaneous lung biopsy confirmed the diagnosis of AFP-producing primary HAL combined with IPF. Systemic treatment according to guidelines for advanced non-small cell lung cancer resulted in a long-term survival.
This case report documents the first occurrence and prognosis of AFP-producing HAL in a patient with IPF. The long-term survival brought by the diagnosis and treatment model in our case may provide significant prognostic value for this rare condition.
产甲胎蛋白的肺肝样腺癌（HAL）是一种罕见的肺癌类型，其特征尚未完全阐明。我们最近遇到一例HAL合并特发性肺纤维化（IPF）的病例，此前从未有过相关报道。
一名66岁男性因咳嗽为主诉前来我院就诊。胸部计算机断层扫描（CT）显示双侧肺内有多个直径为8毫米至20毫米的结节，同时左肺门淋巴结肿大。CT引导下经皮肺活检确诊为产甲胎蛋白的原发性HAL合并IPF。按照晚期非小细胞肺癌指南进行的全身治疗带来了长期生存。
本病例报告记录了IPF患者中产甲胎蛋白的HAL的首次出现及预后情况。我们病例中的诊断和治疗模式所带来的长期生存可能为这种罕见疾病提供重要的预后价值。
