Tanegashima Gaku, Iidaka Toshiko, Muraki Shigeyuki, Horii Chiaki, Oka Hiroyuki, Kawaguchi Hiroshi, Nakamura Kozo, Akune Toru, Tanaka Sakae, Yoshimura Noriko
Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Department of Prevention Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo, 113-8655, Japan.
Osteoarthr Cartil Open. 2025 Jan 25;7(1):100569. doi: 10.1016/j.ocarto.2025.100569. eCollection 2025 Mar.
This study aimed to clarify the trends in the prevalence of knee osteoarthritis (OA) and symptomatic knee OA among the general population using population-based cohort data from baseline and a survey 10 years later.
The baseline survey of the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted from 2005 to 2007; 3040 participants (1061 men and 1979 women; mean age 70.3 years) completed all OA examinations, including a questionnaire of medical information in the present/past and radiographic examination. The fourth survey was performed from 2015 to 2016; 2893 individuals (895 men and 1998 women, mean age 68.9 years) completed assessments identical to those at the baseline survey. Knee OA was defined using the Kellgren-Lawrence grading system.
The prevalence of knee OA was 54.6 % (men, 42.0 %; women, 61.5 %) at the baseline survey and 39.3 % (men, 26.9 %; women, 44.9 %) at the fourth survey, with a significant decrease (p < 0.0001). The prevalence of symptomatic knee OA was 24.3 % (men, 16.9 %; women, 28.3 %) at the baseline survey and 20.6 % (men, 14.2 %; women, 23.5 %) at the fourth survey, showing a similar decrease (p < 0.0001). Thus, the prevalence of knee OA and symptomatic knee OA was lower at the fourth survey than at the baseline survey (p < 0.01).
In the population-based survey with a 10-year interval, the prevalence of knee OA and symptomatic knee OA decreased significantly. This preferable change in OA may suggest rejuvenation in the current population and could contribute to a decrease in the occurrence of disabilities in the future.
本研究旨在利用基于人群的队列数据,从基线情况及10年后的一项调查来阐明普通人群中膝关节骨关节炎(OA)及有症状膝关节OA的患病率趋势。
骨关节炎/骨质疏松症抗残疾研究(ROAD研究)的基线调查于2005年至2007年进行;3040名参与者(1061名男性和1979名女性;平均年龄70.3岁)完成了所有OA检查,包括一份关于当前/过去医疗信息的问卷以及影像学检查。第四次调查于2015年至2016年进行;2893名个体(895名男性和1998名女性,平均年龄68.9岁)完成了与基线调查相同的评估。膝关节OA采用Kellgren-Lawrence分级系统进行定义。
在基线调查时,膝关节OA的患病率为54.6%(男性为42.0%;女性为61.5%),在第四次调查时为39.3%(男性为26.9%;女性为44.9%),患病率显著下降(p<0.0001)。有症状膝关节OA的患病率在基线调查时为24.3%(男性为16.9%;女性为28.3%),在第四次调查时为20.6%(男性为14.2%;女性为23.5%),呈现出类似的下降趋势(p<0.0001)。因此,第四次调查时膝关节OA及有症状膝关节OA的患病率低于基线调查时(p<0.01)。
在间隔10年的基于人群的调查中,膝关节OA及有症状膝关节OA的患病率显著下降。OA的这种良好变化可能表明当前人群更加年轻,并可能有助于未来残疾发生率的降低。