Kitamura Banri, Iidaka Toshiko, Horii Chiaki, Muraki Shigeyuki, Oka Hiroyuki, Kawaguchi Hiroshi, Nakamura Kozo, Akune Toru, Otsuka Yuta, Izumo Takayuki, Tanaka Takao, Rogi Tomohiro, Shibata Hiroshi, Tanaka Sakae, Yoshimura Noriko
Institute for Health Care Science, Suntory Wellness Limited, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan.
Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical & Research Center, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Osteoarthr Cartil Open. 2024 Mar 2;6(2):100454. doi: 10.1016/j.ocarto.2024.100454. eCollection 2024 Jun.
Considering the joint space width and osteophyte area (OPA) of the knee joints of Japanese adults, this study elucidated the ten-year trends in medial minimum joint space width (mJSW) and OPA using data of two independent cohorts from a population-based cohort study.
The baseline survey of the Research on Osteoarthritis/Osteoporosis Against Disability study was conducted from 2005 to 2007; 2975 participants (1041 men, 1934 women) completed all knee osteoarthritis (OA) examinations. The fourth survey was performed from 2015 to 2016; distinct 2445 participants (764 men, 1681 women) completed identical examinations. The medial mJSW and medial tibial OPA were measured bilaterally using an automated system.
The mean medial mJSW (standard deviation) was 3.22 (0.96) mm and 2.65 (0.95) mm at baseline and 3.81 (1.20) mm and 3.13 (1.15) mm in the fourth survey for men and women, respectively. The mean medial mJSW in the fourth survey was significantly greater in both men and women in all age groups than at baseline ( < 0.01). The mean OPAs in men aged 40-49 and 60-69 years and women aged 40-49, 50-59, 60-69, and 70-79 years were significantly smaller in the fourth survey ( < 0.05). The trend in mJSW remained the same even after adjusting for confounding factors in the multivariate analysis, but the trend in OPA was weakened.
A significant improvement in the medial mJSW within 10 years could decrease the incidence and progression of knee OA and prevent the risk of walking disability.
本研究通过一项基于人群的队列研究中两个独立队列的数据，考虑日本成年人膝关节的关节间隙宽度和骨赘面积（OPA），阐明内侧最小关节间隙宽度（mJSW）和OPA的十年变化趋势。
骨关节炎/骨质疏松症抗残疾研究的基线调查于2005年至2007年进行；2975名参与者（1041名男性，1934名女性）完成了所有膝关节骨关节炎（OA）检查。第四次调查于2015年至2016年进行；2445名不同的参与者（764名男性，1681名女性）完成了相同的检查。使用自动系统双侧测量内侧mJSW和内侧胫骨OPA。
男性和女性在基线时的平均内侧mJSW（标准差）分别为3.22（0.96）mm和2.65（0.95）mm，在第四次调查中分别为3.81（1.20）mm和3.13（1.15）mm。在所有年龄组中，第四次调查中男性和女性的平均内侧mJSW均显著高于基线水平（P<0.01）。在第四次调查中，40-49岁和60-69岁男性以及40-49岁、50-59岁、60-69岁和70-79岁女性的平均OPA显著减小（P<0.05）。在多变量分析中调整混杂因素后，mJSW的趋势保持不变，但OPA的趋势减弱。
10年内内侧mJSW的显著改善可降低膝关节OA的发病率和进展，并预防行走残疾风险。
