Wen Lihui, Shin Min-Ho, Kang Ji-Hyoun, Yim Yi-Rang, Kim Ji-Eun, Lee Jeong-Won, Lee Kyung-Eun, Park Dong-Jin, Kim Tae-Jong, Kweon Sun-Seog, Lee Young-Hoon, Yun Yong-Woon, Lee Shin-Seok
Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju, Republic of Korea.
Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea.
PLoS One. 2017 Nov 30;12(11):e0185343. doi: 10.1371/journal.pone.0185343. eCollection 2017.
We assessed whether grip strength was related to various types of radiographic damage in Korean adults with osteoarthritis (OA).
Data from 2,251 subjects enrolled in the Dong-gu study, who had no hand joint pain, were analyzed to investigate the relationship between grip strength and OA. Hand grip strength was measured using a hand-held dynamometer, and radiographs of the hand and knee were scored according to a semi-quantitative grading system. Multiple linear regressions were used to explore associations between grip strength and radiographic features of OA.
Grip strength in men and women was negatively related to hand (both p < 0.001) and knee (men, p < 0.001; women, p = 0.010) OA after adjusting for confounders. Hand (men, p < 0.001; women, p = 0.001) and knee (both p < 0.001) joint space narrowing (JSN) showed the strongest associations with low grip strength, regardless of gender. Moreover, the severity of hand osteophytes in women (p = 0.001), and subchondral cysts (men, p < 0.001) was correlated with low grip strength in both genders.
Among subjects without hand joint pain, low grip strength was associated significantly with hand and knee radiographic OA, regardless of gender. Among all types of OA radiographic damage, low grip strength showed the strongest association with JSN.
我们评估了握力是否与韩国骨关节炎（OA）成年患者的各种类型影像学损伤相关。
对来自东古研究的2251名无手部关节疼痛的受试者的数据进行分析，以研究握力与OA之间的关系。使用手持式测力计测量握力，并根据半定量分级系统对手部和膝部的X光片进行评分。采用多元线性回归来探讨握力与OA影像学特征之间的关联。
在调整混杂因素后，男性和女性的握力与手部OA（均p<0.001）和膝部OA（男性，p<0.001；女性，p = 0.010）呈负相关。无论性别如何，手部（男性，p<0.001；女性，p = 0.001）和膝部（均p<0.001）关节间隙变窄（JSN）与低握力的关联最强。此外，女性手部骨赘的严重程度（p = 0.001）以及男性的软骨下囊肿（p<0.001）与两性的低握力均相关。
在无手部关节疼痛的受试者中，无论性别，低握力均与手部和膝部影像学OA显著相关。在所有类型的OA影像学损伤中，低握力与JSN的关联最强。
