Xiong Zongliang, Ling Shanshan, Li Caiwu, Deng Linhua, He Ming, Wang Chengdong, Li Desheng, Chen Zhengli
Experimental Animal Disease Model Research Laboratory, School of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Key Laboratory of State Forestry and Grassland Administration on the Giant Panda, China Conservation and Research Center for the Giant Panda, Chengdu, China.
Front Vet Sci. 2025 Feb 4;11:1500679. doi: 10.3389/fvets.2024.1500679. eCollection 2024.
A female giant panda presented with a large, hard mass on the right cheek, which was investigated at the Dujiangyan Base of the China Conservation and Research Center for the Giant Panda with computed tomography (CT) scans and biopsy of the oral mass, as well as venous blood sampling. Hematological tests revealed elevated levels of the tumor marker CA724, along with infectious disease, anemia, hepatic damage, and renal failure. Imaging studies identified a soft tissue mass in the right cheek area. Macroscopic pathological changes, histopathological features, and immunohistochemical analysis were consistent with a low-grade malignant fibrosarcoma within the oral cavity, indicating malignant potential. This case represents the first report of an oral tumor in a giant panda, providing valuable data for future clinical diagnoses of neoplasms in this species.
一只雌性大熊猫右侧脸颊出现一个大的硬块，在中国大熊猫保护研究中心都江堰基地对其进行了计算机断层扫描（CT）、口腔肿物活检以及静脉采血检查。血液学检查显示肿瘤标志物CA724水平升高，同时伴有传染病、贫血、肝损伤和肾衰竭。影像学研究发现右侧脸颊区域有一个软组织肿块。大体病理变化、组织病理学特征和免疫组化分析均符合口腔内低级别恶性纤维肉瘤，提示有恶变潜能。该病例是大熊猫口腔肿瘤的首例报告，为该物种未来肿瘤的临床诊断提供了有价值的数据。
