Xiong Zongliang, Ling Shanshan, Li Caiwu, Deng Linhua, Wei Tingting, He Ming, Wang Chengdong, Luo Qihui, Li Desheng, Cheng Zhengli
Experimental Animal Disease Model Research Laboratory, School of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Key Laboratory of State Forestry and Grassland Administration on the Giant Panda, China Conservation and Research Center for the Giant Panda, Chengdu, China.
Front Vet Sci. 2025 Feb 24;12:1542700. doi: 10.3389/fvets.2025.1542700. eCollection 2025.
During routine health examinations, an abnormal growth was detected in the oral cavity of a male giant panda. A malignant tumor, osteosarcoma, was diagnosed through CT (computed tomography) scans and pathological examination of biopsy samples. After two attempts at "tumor reduction surgery" with no improvement, the condition stabilized following particle implantation and arterial infusion interventional therapy. The following year, a CT scan revealed a highly similar mass in the left lumbar muscle, which showed no improvement despite chemotherapy, leading to death 1 month later. Post-mortem examination and tissue pathological diagnosis confirmed osteosarcoma characteristics in the facial, lumbar, and liver masses. The giant panda was diagnosed with osteosarcoma with liver metastasis based on integrated pathological and gross anatomical observations. This case represents the first report of osteosarcoma with liver metastasis in a giant panda, providing valuable data and references for future clinical diagnosis and treatment of tumors in giant pandas.
在常规健康检查中，一只雄性大熊猫口腔内检测到异常肿物。通过CT（计算机断层扫描）扫描和活检样本的病理检查，诊断为恶性肿瘤骨肉瘤。在进行了两次“减瘤手术”均无改善后，经粒子植入和动脉灌注介入治疗，病情得到稳定。次年，CT扫描显示左腰大肌出现高度相似肿物，尽管进行了化疗仍无改善，1个月后死亡。尸检和组织病理诊断证实面部、腰部和肝脏肿物具有骨肉瘤特征。综合病理和大体解剖观察，该大熊猫被诊断为骨肉瘤伴肝转移。本病例是大熊猫骨肉瘤伴肝转移的首例报告，为今后大熊猫肿瘤的临床诊断和治疗提供了有价值的数据和参考。
