我们对太空中椎间盘的力学生物学的了解是否比对地球上的更多？
Do we know more about the mechanobiology of the intervertebral disc in space than on Earth?
作者信息
Holsgrove Timothy Patrick, Ebisch Isabelle, Lazaro-Pacheco Daniela
机构信息
Department of Engineering, Faculty of Environment, Science and Economy University of Exeter Exeter UK.
出版信息
JOR Spine. 2025 Feb 18;8(1):e70024. doi: 10.1002/jsp2.70024. eCollection 2025 Mar.
Abstract
This work provides a perspective on the loading protocols used in whole-organ interverterbal disc culture studies using bioreactors. We put this in the context of in vivo spinal loading, and we put forward the case that the majority of previous bioreactor studies have more in common with spinal loading in space than on Earth. Finally, we provide an outlook for the future of bioreactor research, to provide data more relevant to spinal loading on Earth, and maximize the translational potential of findings to the clinical setting.
摘要
这项工作提供了关于使用生物反应器进行全器官椎间盘培养研究中所采用加载方案的观点。我们将其置于体内脊柱加载的背景下，并提出这样的观点：以往大多数生物反应器研究与太空中的脊柱加载情况有更多共同之处，而非与地球上的情况。最后，我们对生物反应器研究的未来进行了展望，旨在提供与地球上脊柱加载更相关的数据，并最大限度地提高研究结果向临床应用转化的潜力。
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