Rocha L R, Calixto S L, Ladosky W
Gen Comp Endocrinol. 1985 May;58(2):179-85. doi: 10.1016/0016-6480(85)90333-8.
The influence of catecholamines on the estrogenized uterus of the Didelphis albiventris was studied in an in vitro preparation. It was observed that the D. albiventris uterus reacts to both alpha and beta-adrenergic agonists but not dopaminergic ones. Adrenaline is more potent in inducing a contractile response than is noradrenaline. Isoprenaline, when added to the bath, is able neither to induce a response nor to interfere with a contraction previously induced by acetylcholine. It is, however, able to block the contractile response brought about by electric field stimulation. In an in vitro preparation from animals previously treated with estrogen and progesterone, the sensitivity to both alpha- and beta-adrenergic drugs was greatly increased. This is demonstrated by a higher pD2 in progesteronized animals compared to that in estrogenized ones. The increased sensitivity to beta-agonists after progesterone treatment is illustrated by the fact that isoprenaline is effective in inducing a relaxation of the uterus, in these conditions. These results indicate that the Brazilian opossum should be included among those animals in which progesterone enhances uterine sensitivity to drugs.
在体外制备中研究了儿茶酚胺对白腹袋鼬雌激素化子宫的影响。观察到白腹袋鼬子宫对α和β肾上腺素能激动剂有反应，但对多巴胺能激动剂无反应。肾上腺素诱导收缩反应的效力比去甲肾上腺素更强。异丙肾上腺素加入浴液中时，既不能诱导反应，也不能干扰先前由乙酰胆碱诱导的收缩。然而，它能够阻断电场刺激引起的收缩反应。在先前用雌激素和孕酮处理过的动物的体外制备中，对α和β肾上腺素能药物的敏感性大大增加。与雌激素化动物相比，孕酮化动物的pD2更高，这证明了这一点。在这些情况下，异丙肾上腺素能有效诱导子宫松弛，这一事实说明了孕酮处理后对β激动剂的敏感性增加。这些结果表明，巴西负鼠应被列入孕酮增强子宫对药物敏感性的动物之列。
