Hvingelby Victor S, Kjeldsen Pernille, Bergholt Bo, Schechtmann Gaston Andres, Danielsen Erik Hvid, Møller Mette, Johnsen Erik Lisbjerg, Mardosiene Skirmante, Lund Torben Ellegaard, Grauballe Dora, Geneser Michael, Sørensen Tina Vincens, Bak Lisa Østergaard, Andreasen Martin, Andersen Anne Sofie Møller, Andersen Lone, Meier Kaare, Juhl Niels, Tankisi Alp, Jespersen Bo, Eriksen Christian Fenger, Rasmussen Mads, Eriksen Winnie Bechmann, Barrutia Birgitte, Kromann Mette, Baandrup Ida, Bjørn Jette, Stjernholm Rie, Bræmer-Madsen Charlotte, Jørgensen Signe Mygdal, Sørensen Jens Christian Hedemann, Glud Andreas Nørgaard
Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark.
Center of Experimental Neuroscience, Aarhus University Hospital, Aarhus, Denmark.
Mov Disord Clin Pract. 2025 Jul;12(7):922-927. doi: 10.1002/mdc3.70012. Epub 2025 Feb 19.
Essential tremor is the most common hyperkinetic movement disorder. Magnetic resonance imaging-guided focused ultrasound (MRgFUS) has emerged as second-line therapy.
The aim was to obtain the results of the first 108 patients treated with MRgFUS in Denmark.
Data were entered in a quality assurance database at baseline and 3, 6, and 12 months. Clinician- and patient-rated treatment efficacy was evaluated using the Fahn-Marin-Tolosa (FMT) scale and the Patient Global Impression of Change.
A total of 108 persons have currently been treated. Tremor improved by a total mean 6.39 points (95% confidence interval [CI]: 5.01;7.76, P < 0.00001) and 9.63 points (95% CI: 7.60;11.66, P < 0.00001), 10.42 (95% CI: 9.06;11.79, P < 0.00001), and 26.45 (95% CI: 22.46;30.43, P < 0.00001) for FMT parts A, B, and C, respectively, at 3 months. Side effects occurred in 65.7% of patients at 3 months and 33.7% at 12 months.
Our findings are in line with existing evidence. Questions regarding persistence of gait- and balance-related side effects remain.
特发性震颤是最常见的运动亢进性运动障碍。磁共振成像引导聚焦超声（MRgFUS）已成为二线治疗方法。
旨在获得丹麦首批108例接受MRgFUS治疗患者的结果。
在基线以及3、6和12个月时将数据录入质量保证数据库。使用法恩 - 马林 - 托洛萨（FMT）量表和患者总体变化印象评估临床医生和患者评定的治疗效果。
目前共有108人接受了治疗。在3个月时，FMT A、B和C部分的震颤分别平均改善6.39分（95%置信区间[CI]：5.01；7.76，P < 0.00001）、9.63分（95% CI：7.60；11.66，P < 0.00001）、10.42分（95% CI：9.06；11.79，P < 0.00001）和26.45分（95% CI：22.46；30.43，P < 0.00001）。3个月时65.7%的患者出现副作用，12个月时为33.7%。
我们的研究结果与现有证据一致。关于步态和平衡相关副作用的持续性问题仍然存在。
