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同步性胰腺腺癌和十二指肠黏膜相关淋巴组织淋巴瘤：一例报告

Synchronous pancreatic adenocarcinoma and duodenal mucosa‑associated lymphoid tissue lymphoma: A case report.

作者信息

Lee Yong-Pyo, Lee Jun Su, Kim Hong-Sik, Han Hye Sook, Lee Jisun, Woo Chang Gok, Lee Ok-Jun, Son Seung-Myoung

机构信息

Departments of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.

Department of Radiology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.

出版信息

Medicine (Baltimore). 2024 Dec 27;103(52):e41173. doi: 10.1097/MD.0000000000041173.

DOI:10.1097/MD.0000000000041173
PMID:39969306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11688084/
Abstract

RATIONALE

Duodenal mucosa-associated lymphoid tissue (MALT) lymphoma is a rare condition. Simultaneous presence of pancreatic ductal adenocarcinoma along with duodenal MALT lymphoma has not been documented in the scientific literature. We report an exceptionally rare case of synchronous duodenal MALT lymphoma and pancreatic ductal adenocarcinoma.

PATIENT CONCERNS

A 75-year-old man was referred to our hospital with dyspepsia and weight loss.

DIAGNOSES

Esophagogastroduodenoscopy was performed, revealing synchronous tumor comprising pancreatic ductal adenocarcinoma and MALT lymphoma of the duodenum.

INTERVENTIONS

Given that the pancreatic carcinoma would be the primary determinant of prognosis, we prioritized treatment of the pancreatic carcinoma. Consequently, we performed a Whipple operation first. Post-operative pathologic examination revealed metastasis of pancreatic cancer to peri-pancreatic lymph nodes, whereas the MALT lymphoma was localized to the duodenum; therefore, only adjuvant chemotherapy for pancreatic cancer was performed.

OUTCOMES

To date, the patient has had no recurrence of either the pancreatic cancer or the MALT lymphoma.

LESSONS

To the best of our knowledge, this is the first case to be reported. Awareness of this co-occurrence may help diagnosis and management of similar cases.

摘要

理论依据

十二指肠黏膜相关淋巴组织（MALT）淋巴瘤是一种罕见疾病。科学文献中尚未记载十二指肠MALT淋巴瘤与胰腺导管腺癌同时存在的情况。我们报告了一例极为罕见的同步性十二指肠MALT淋巴瘤和胰腺导管腺癌病例。

患者情况

一名75岁男性因消化不良和体重减轻被转诊至我院。

诊断

进行了食管胃十二指肠镜检查，发现同步性肿瘤，包括胰腺导管腺癌和十二指肠MALT淋巴瘤。

干预措施

鉴于胰腺癌将是预后的主要决定因素，我们将胰腺癌的治疗放在首位。因此，我们首先进行了胰十二指肠切除术。术后病理检查显示胰腺癌转移至胰腺周围淋巴结，而MALT淋巴瘤局限于十二指肠；因此，仅对胰腺癌进行了辅助化疗。

结果

迄今为止，该患者的胰腺癌和MALT淋巴瘤均未复发。

经验教训

据我们所知，这是首例报告病例。认识到这种同时出现的情况可能有助于类似病例的诊断和管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/11688084/288a5adf07eb/medi-103-e41173-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/11688084/84fca83cbafc/medi-103-e41173-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/11688084/288a5adf07eb/medi-103-e41173-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/11688084/84fca83cbafc/medi-103-e41173-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/11688084/7ffe2235e503/medi-103-e41173-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/11688084/e87db8f6ae0b/medi-103-e41173-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e6/11688084/766f4d276f14/medi-103-e41173-g004.jpg
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本文引用的文献

1
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2
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J Gastroenterol Hepatol. 2021 Feb;36(2):406-412. doi: 10.1111/jgh.15157. Epub 2020 Jul 21.
3
JSH practical guidelines for hematological malignancies, 2018: II. Lymphoma-2. Marginal zone lymphoma (MALT lymphoma/extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue and splenic marginal zone lymphoma).
《2018年日本血液学会血液系统恶性肿瘤实用指南：II. 淋巴瘤-2. 边缘区淋巴瘤（黏膜相关淋巴组织边缘区淋巴瘤/结外黏膜相关淋巴组织边缘区淋巴瘤及脾边缘区淋巴瘤）》
Int J Hematol. 2019 Oct;110(4):393-405. doi: 10.1007/s12185-019-02719-6. Epub 2019 Aug 19.
4
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Tohoku J Exp Med. 2018 Jul;245(3):159-165. doi: 10.1620/tjem.245.159.
5
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6
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7
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