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宫颈管小叶状腺性增生:两例报告及文献复习

Lobular endocervical glandular hyperplasia: Two case report and literature review.

作者信息

Tang Shenglan, Jiang Xuelu, Wang Xue

机构信息

Department of the First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People's Republic of China.

The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang Province, People's Republic of China.

出版信息

Medicine (Baltimore). 2024 Dec 27;103(52):e40968. doi: 10.1097/MD.0000000000040968.

DOI:10.1097/MD.0000000000040968
PMID:39969352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11688035/
Abstract

RATIONALE

Lobular endocervical glandular hyperplasia is a rare proliferative lesion of the endocervical glands with an unclear pathogenesis. The condition lacks specific clinical manifestations and signs and often leading to clinical underdiagnosis and misdiagnosis.

PATIENT CONCERNS

A 27-year-old female patient presented with a history of abnormal vaginal bleeding over the previous 3 months. An ultrasound examination revealed the presence of a cystic solid structure in the posterior wall of the cervix.The second patient is a 25-year-old woman who has undergone 3 cervical cystectomies over the past 9 years due to recurrent cervical cysts. It is regrettable to report that the cyst has now recurred.

DIAGNOSES

Lobular endocervical glandular hyperplasia.

INTERVENTIONS

In consideration of the fertility needs of both patients, the gynecologists conducted a comprehensive imaging evaluation and detailed preoperative discussion, and performed ultrasound-guided hysteroscopic excision of cervical lesions and transvaginal excision of cervical lesions.

OUTCOMES

Following treatment, the 2 patients exhibited a complete resolution of their clinical symptoms. Subsequent follow-up examinations demonstrated that both patients were exhibiting favorable outcomes.

LESSONS

The objective of this study is to present 2 cases of lobular endocervical glandular hyperplasia in order to facilitate a greater understanding of this rare disease among gynecologists. Furthermore, this study will describe the potential use of ultrasound-guided hysteroscopic excision of cervical lesions and transvaginal hysteroscopic excision of cervical lesions as a treatment modality for lobular endocervical glandular hyperplasia patients with fertility needs.

摘要

理论依据

宫颈管小叶状腺性增生是一种罕见的宫颈管腺增生性病变,发病机制尚不明确。该病症缺乏特异性临床表现和体征,常导致临床漏诊和误诊。

患者情况

一名27岁女性患者,有前3个月阴道异常出血史。超声检查显示宫颈后壁有一囊实性结构。第二位患者是一名25岁女性,因复发性宫颈囊肿在过去9年里接受了3次宫颈囊肿切除术。遗憾的是,囊肿现在又复发了。

诊断

宫颈管小叶状腺性增生。

干预措施

考虑到两位患者的生育需求,妇科医生进行了全面的影像学评估和详细的术前讨论,并实施了超声引导下宫腔镜宫颈病变切除术和经阴道宫颈病变切除术。

结果

治疗后,2例患者临床症状完全缓解。随后的随访检查表明,两位患者均预后良好。

经验教训

本研究的目的是展示2例宫颈管小叶状腺性增生病例,以便妇科医生更好地了解这种罕见疾病。此外,本研究将描述超声引导下宫腔镜宫颈病变切除术和经阴道宫腔镜宫颈病变切除术作为有生育需求的宫颈管小叶状腺性增生患者的一种治疗方式的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a5/11688035/f09f73d2c34c/medi-103-e40968-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a5/11688035/0d4c3c1441ef/medi-103-e40968-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a5/11688035/7c211a346464/medi-103-e40968-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a5/11688035/126b2250a60c/medi-103-e40968-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a5/11688035/a5cf87111a46/medi-103-e40968-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a5/11688035/f09f73d2c34c/medi-103-e40968-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a5/11688035/0d4c3c1441ef/medi-103-e40968-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a5/11688035/7c211a346464/medi-103-e40968-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a5/11688035/126b2250a60c/medi-103-e40968-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a5/11688035/a5cf87111a46/medi-103-e40968-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a5/11688035/f09f73d2c34c/medi-103-e40968-g005.jpg

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本文引用的文献

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2020 WHO Classification of Female Genital Tumors.《2020年世界卫生组织女性生殖器官肿瘤分类》
Geburtshilfe Frauenheilkd. 2021 Oct;81(10):1145-1153. doi: 10.1055/a-1545-4279. Epub 2021 Oct 6.
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International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.国际宫颈内膜腺癌标准和分类(IECC):宫颈内膜浸润性腺癌的一种新的发病机制分类。
Am J Surg Pathol. 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986.
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Usefulness of a management protocol for patients with cervical multicystic lesions: A retrospective analysis of 94 cases and the significance of GNAS mutation.
宫颈多囊性病变患者管理方案的有效性:94例回顾性分析及GNAS突变的意义
J Obstet Gynaecol Res. 2016 Nov;42(11):1588-1598. doi: 10.1111/jog.13083. Epub 2016 Oct 8.
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A Detailed Immunohistochemical Analysis of a Large Series of Cervical and Vaginal Gastric-type Adenocarcinomas.一大系列宫颈和阴道胃型腺癌的详细免疫组织化学分析
Am J Surg Pathol. 2016 May;40(5):636-44. doi: 10.1097/PAS.0000000000000578.
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Endocervical glandular lesions exhibiting gastric differentiation: an emerging spectrum of benign, premalignant, and malignant lesions.表现为胃分化的宫颈内膜腺病变:一种新兴的良性、癌前病变和恶性病变谱。
Adv Anat Pathol. 2013 Jul;20(4):227-37. doi: 10.1097/PAP.0b013e31829c2d66.
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Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings.术前鉴别诊断宫颈微小偏离性腺癌与宫颈管内柱状腺上皮增生:一项多中心临床病理与磁共振成像研究。
Int J Gynecol Cancer. 2011 Oct;21(7):1287-96. doi: 10.1097/IGC.0b013e31821f746c.
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Peutz-Jeghers syndrome: a systematic review and recommendations for management.佩吉特-杰格斯综合征:系统评价及管理建议。
Gut. 2010 Jul;59(7):975-86. doi: 10.1136/gut.2009.198499.
8
Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia.女性生殖道同步性和多灶性黏液性病变的重新评估:与胃化生密切相关。
Histopathology. 2009 Jan;54(2):184-91. doi: 10.1111/j.1365-2559.2008.03202.x.
9
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Am J Surg Pathol. 2007 May;31(5):664-72. doi: 10.1097/01.pas.0000213434.91868.b0.